Rodgers Alexander D, Cummins Adrian G
Department of Gastroenterology and Hepatology, The Queen Elizabeth Hospital, Woodville Road, Woodville South, South Australia 5011, Australia.
Dig Dis Sci. 2007 Sep;52(9):2063-8. doi: 10.1007/s10620-006-9691-2. Epub 2007 Apr 11.
The aim of this study was to prospectively evaluate the correlation between clinical scoring systems and C-reactive protein (CRP) in inflammatory bowel disease. The modified Harvey-Bradshaw index was used in 40 patients (58 assessments) with Crohn's disease, and the Lichtiger score in 29 patients (36 assessments) with ulcerative colitis. In ulcerative colitis, CRP was elevated in 14%, 42%, 64%, and 83%, respectively, of subjects with quiescent, mild, moderate, and severe disease. There was a linear correlation of log(CRP) with clinical score except for proctitis. In Crohn's disease, CRP was elevated in 54%, 70%, 75%, and 100%, respectively, of subjects with quiescent, mild, moderate, and severe disease. We conclude that the clinical score has a good correlation with CRP in ulcerative colitis except for proctitis, whereas clinical score has a poor correlation with CRP in Crohn's disease, particularly in those with clinically quiescent, fibrostenotic, and ileal disease.
本研究的目的是前瞻性评估炎症性肠病临床评分系统与C反应蛋白（CRP）之间的相关性。40例克罗恩病患者（共进行58次评估）采用改良的哈维-布拉德肖指数，29例溃疡性结肠炎患者（共进行36次评估）采用利希蒂格评分。在溃疡性结肠炎中，静止期、轻度、中度和重度疾病患者的CRP升高比例分别为14%、42%、64%和83%。除直肠炎外，log(CRP)与临床评分呈线性相关。在克罗恩病中，静止期、轻度、中度和重度疾病患者的CRP升高比例分别为54%、70%、75%和100%。我们得出结论，除直肠炎外，溃疡性结肠炎的临床评分与CRP具有良好的相关性，而克罗恩病的临床评分与CRP相关性较差，尤其是在临床静止、纤维狭窄和回肠疾病患者中。
