Jun Dae Won, Lee Oh Young, Lee Young Yul, Choi Ho Soon, Kim Tae Hwa, Yoon Byung Chul
Department of Internal Medicine, Hanyang University Hospital, Seoul, 133-792, Republic of Korea.
Dig Dis Sci. 2007 Oct;52(10):2866-72. doi: 10.1007/s10620-006-9651-x. Epub 2007 Apr 12.
The purpose of this study was to examine the changes in gastric ghrelin and leptin with respect to Helicobacter pylori infection and whether such changes affect the plasma levels of leptin and ghrelin. In addition, we examined the relationship between changes in gastric mucosal ghrelin and leptin levels and gastrointestinal symptoms. Sixty-three patients diagnosed with chronic gastritis were enrolled in the study. Twenty-nine patients were Helicobacter pylori negative and 34 were Helicobacter pylori positive. Expression of ghrelin and leptin mRNA in the gastric mucosa was measured using endoscopic biopsies from the fundus. Plasma levels of ghrelin and leptin were measured by radioimmunoassay. Expression of leptin mRNA in the gastric mucosa was significantly higher in Helicobacter pylori-positive patients than in negative patients (0.38 +/- 0.17 vs. 0.24 +/- 0.12, p = 0.039). The expression of ghrelin was lower in positive patients than in the negative group, although this difference was not significant (p = 0.07). However, there was no significant difference in plasma leptin and ghrelin levels. Gastric mucosal ghrelin mRNA expression was significantly lower in patients with dyspepsia than in those without (0.15 +/- 0.11 vs. 0.23 +/- 0.20, p = 0.05). Helicobacter pylori infection and gastrointestinal symptoms could be associated with leptin and ghrelin expression in the gastric mucosa.
本研究的目的是检测幽门螺杆菌感染情况下胃内胃饥饿素和瘦素的变化，以及这些变化是否会影响血浆中瘦素和胃饥饿素的水平。此外，我们还研究了胃黏膜胃饥饿素和瘦素水平的变化与胃肠道症状之间的关系。63例被诊断为慢性胃炎的患者纳入本研究。29例患者幽门螺杆菌阴性，34例患者幽门螺杆菌阳性。使用来自胃底的内镜活检组织测定胃黏膜中胃饥饿素和瘦素mRNA的表达。采用放射免疫分析法测定血浆中胃饥饿素和瘦素的水平。幽门螺杆菌阳性患者胃黏膜中瘦素mRNA的表达显著高于阴性患者（0.38±0.17 vs. 0.24±0.12，p = 0.039）。阳性患者中胃饥饿素的表达低于阴性组，尽管这种差异不显著（p = 0.07）。然而，血浆瘦素和胃饥饿素水平没有显著差异。消化不良患者胃黏膜中胃饥饿素mRNA的表达显著低于无消化不良症状的患者（0.15±0.11 vs. 0.23±0.20，p = 0.05）。幽门螺杆菌感染和胃肠道症状可能与胃黏膜中瘦素和胃饥饿素的表达有关。
