Salles Nathalie, Ménard Armelle, Georges Agnès, Salzmann Mélanie, de Ledinghen Victor, de Mascarel Antoine, Emeriau Jean-Paul, Lamouliatte Hervé, Mégraud Francis
INSERM ERI 10, Laboratoire de Bactériologie, Université Victor Segalen Bordeaux 2, Bât 2B RDC Zone Nord, 33076 Bordeaux cedex, France.
J Gerontol A Biol Sci Med Sci. 2006 Nov;61(11):1144-50. doi: 10.1093/gerona/61.11.1144.
The aim of the study was to investigate the relationship between gastritis and leptin and ghrelin in elderly patients. Patients older than 75 years undergoing an endoscopy were included. We reported data on nutritional status and Helicobacter pylori infection diagnosis (serology, 13C-urea breath test, culture, histology, and polymerase chain reaction on gastric biopsies). Gastric messenger RNA expression of leptin and ghrelin were quantified by real-time polymerase chain reaction. Sixty-two patients were included (84.7 +/- 5.2 years). H. pylori infection was associated with decreased gastric expression of leptin (p = .021), ghrelin (p =.002), and plasma ghrelin levels (p = .018). Atrophy was associated with decreased gastric leptin (p = .007) and ghrelin (p = .02). H. pylori infection correlated negatively with patient energy intake (r = -0.36; p = .001) and body mass index (r = -0.34; p = .018). The negative association between ghrelin and H. pylori infection may be related to a higher prevalence of atrophy and raises the possibility that H. pylori may be contributing to undernutrition in some older people.
本研究的目的是调查老年患者胃炎与瘦素和胃饥饿素之间的关系。纳入年龄超过75岁且接受内镜检查的患者。我们报告了营养状况和幽门螺杆菌感染诊断（血清学、¹³C尿素呼气试验、培养、组织学以及胃活检的聚合酶链反应）的数据。通过实时聚合酶链反应对胃中瘦素和胃饥饿素的信使核糖核酸表达进行定量。共纳入62例患者（84.7±5.2岁）。幽门螺杆菌感染与胃中瘦素表达降低相关（p = 0.021）、胃饥饿素表达降低相关（p = 0.002）以及血浆胃饥饿素水平降低相关（p = 0.018）。萎缩与胃中瘦素降低相关（p = 0.007）以及胃饥饿素降低相关（p = 0.02）。幽门螺杆菌感染与患者能量摄入呈负相关（r = -0.36；p = 0.001）以及与体重指数呈负相关（r = -0.34；p = 0.018）。胃饥饿素与幽门螺杆菌感染之间的负相关可能与萎缩的较高患病率有关，并增加了幽门螺杆菌可能导致一些老年人营养不良的可能性。
