Kang Dae Gill, Sohn Eun Jin, Lee An Sook, Kim Jin Sook, Lee Dae Ho, Lee Ho Sub
Professional Graduate School of Oriental, Wonkwang University, Iksan, Jeonbuk, 570-749, Korea.
Am J Chin Med. 2007;35(2):265-77. doi: 10.1142/S0192415X07004801.
Feeding high fructose (Frc) to rats induces a moderate increase in blood pressure, which is associated with insulin resistance. The present study was designed to evaluate the effect of the methanol extract of Sorbus commixta cortex (MSC) on vascular inflammation in a rat model of the metabolic syndrome induced by a high Frc-diet. Male Sprague-Dawley rats were divided into 4 groups and treated for 7 weeks as follows: 1) control, 2) high Frc-diet group, 3) Frc/MSC1 group; high Frc-diet group treated with MSC (100 mg/kg/day), and 4) Frc/MSC2 group; high Frc-diet group treated with MSC (200 mg/kg/day). High Frc-induced decreases of the expression level of aortic endothelial nitric oxide synthase (ecNOS) while the production of cyclic GMP (cGMP) was restored by treatment with MSC. On the contrary, increases of the expression level of endothelin-1 (ET-1) in the aorta, the transcription factor, the cytokine related with vascular inflammation, and the adhesion molecules were suppressed by MSC treatment. Moreover, MSC treatment was shown to lessen the thickening noted in the aortic intima and media of the high Frc-diet group. Our findings suggest that MSC may have an anti-vascular inflammatory effect on rats with a high Frc-induced metabolic syndrome.
给大鼠喂食高果糖（Frc）会使其血压适度升高，这与胰岛素抵抗有关。本研究旨在评估花楸树皮甲醇提取物（MSC）对高Frc饮食诱导的代谢综合征大鼠模型血管炎症的影响。将雄性Sprague-Dawley大鼠分为4组，并进行如下7周的处理：1）对照组，2）高Frc饮食组，3）Frc/MSC1组；用MSC（100毫克/千克/天）处理的高Frc饮食组，以及4）Frc/MSC2组；用MSC（200毫克/千克/天）处理的高Frc饮食组。高Frc诱导主动脉内皮型一氧化氮合酶（ecNOS）表达水平降低，而用MSC处理可恢复环磷酸鸟苷（cGMP）的产生。相反，MSC处理可抑制主动脉中内皮素-1（ET-1）、转录因子、与血管炎症相关的细胞因子以及黏附分子表达水平的升高。此外，MSC处理可减轻高Frc饮食组大鼠主动脉内膜和中膜的增厚。我们的研究结果表明，MSC可能对高Frc诱导的代谢综合征大鼠具有抗血管炎症作用。
