杜诺凡病（腹股沟肉芽肿）中的人类白细胞抗原
HLA antigens in donovanosis (granuloma inguinale).
作者信息
O'Farrell N, Hammond M
机构信息
City Health STD Department, King Edward VIII Hospital, Durban, South Africa.
出版信息
Genitourin Med. 1991 Oct;67(5):400-2. doi: 10.1136/sti.67.5.400.
OBJECTIVE
To compare the frequencies of HLA antigens in patients with donovanosis and in controls.
DESIGN
HLA Class I, Class II and DQ antigens were detected in patients with genital ulceration caused by donovanosis and in a control group.
SETTING
City Health STD Clinic, King Edward VIII Hospital, Durban, South Africa. Participants--Sixty (47 men, 13 women) patients with donovanosis.
RESULTS
HLA B57 was detected in nine of 60 (15%) with donovanosis and 75 of 1478 (5.1%) controls (RR = 3.3 chi 2 = 11.0, p = 0.001, p corrected = 0.026).
CONCLUSIONS
A possible link between donovanosis and HLA B57 could be explained by coexisting alleles or immune response genes in linkage disequilibrium altering disease susceptibility.
目的
比较杜诺凡病患者与对照组中HLA抗原的频率。
设计
检测杜诺凡病所致生殖器溃疡患者及对照组的HLA I类、II类和DQ抗原。
地点
南非德班爱德华八世国王医院市立卫生性病诊所。参与者——60例（47名男性，13名女性）杜诺凡病患者。
结果
60例杜诺凡病患者中有9例（15%）检测到HLA B57，1478例对照组中有75例（5.1%）检测到（相对危险度=3.3，卡方=11.0，p=0.001，校正p=0.026）。
结论
杜诺凡病与HLA B57之间的可能联系可通过处于连锁不平衡状态的共存等位基因或免疫反应基因改变疾病易感性来解释。
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