Casale Roberto, Symeonidou Zaira, Ferfeli Sofia, Micheli Fabrizio, Scarsella Paolo, Paladini Antonella
Opusmedica Persons, Care and Research, NPO, 29121, Piacenza, Italy.
Department of Physical and Rehabilitation Medicine, 251 General Hospital of Hellenic Airforce, Athens, Greece.
Pain Ther. 2021 Jun;10(1):225-242. doi: 10.1007/s40122-021-00239-y. Epub 2021 Feb 16.
The present paper focuses on the possible contribution of food compounds to alleviate symptomatic pains. Chronic pain can more easily be linked to anticipatory signals such as thirst and hunger than it is to sensory perceptions as its chronicity makes it fall under the behavioural category rather than it does senses. In fact, pain often negatively affects one's normal feeding behavioural patterns, both directly and indirectly, as it is associated with pain or because of its prostrating effects.
Several nutraceuticals and Foods for Special Medical Purposes (FSMPs) are reported to have significant pain relief efficacy with multiple antioxidant and anti-inflammatory properties. Apart from the aforementioned properties, amino acids, fatty acids, trace elements and vitamins may have a role in the modulation of pain signals to and within the nervous system.
In our opinion, this review could be of great interest to clinicians, as it offers a complementary perspective in the management of pain. Trials with well-defined patient and symptoms selection and a robust pharmacological design are pivotal points to let these promising compounds become better accepted by the medical community.
本文聚焦于食物化合物在缓解症状性疼痛方面的潜在作用。与感觉认知相比，慢性疼痛更容易与诸如口渴和饥饿等预期信号相关联，因为其慢性使其属于行为范畴而非感觉范畴。事实上，疼痛常常直接或间接地对人的正常进食行为模式产生负面影响，这要么是因为它与疼痛相关，要么是由于其使人衰弱的作用。
据报道，几种营养保健品和特殊医学用途食品（FSMPs）具有显著的止痛功效，并具有多种抗氧化和抗炎特性。除了上述特性外，氨基酸、脂肪酸、微量元素和维生素可能在调节传入神经系统和在神经系统内的疼痛信号方面发挥作用。
我们认为，这篇综述可能会引起临床医生的极大兴趣，因为它为疼痛管理提供了一个补充视角。进行有明确患者和症状选择且有强大药理学设计的试验，是让这些有前景的化合物被医学界更好接受的关键点。
