Department of Health, Human Performance and Recreation, Baylor University, One Bear Place, Box 97313, Waco, TX 76798-7313, USA.
Human Performance Lab, Exercise & Sport Science Department, University of Mary-Hardin Baylor, Belton, Texas 76513, USA.
J Int Soc Sports Nutr. 2011 Jun 20;8(1):8. doi: 10.1186/1550-2783-8-8.
The purpose of this study was to determine whether sedentary obese women with knee OA initiating an exercise and weight loss program may experience more beneficial changes in body composition, functional capacity, and/or markers of health following a higher protein diet compared to a higher carbohydrate diet with or without GCM supplementation.
Thirty sedentary women (54 ± 9 yrs, 163 ± 6 cm, 88.6 ± 13 kg, 46.1 ± 3% fat, 33.3 ± 5 kg/m2) with clinically diagnosed knee OA participated in a 14-week exercise and weight loss program. Participants followed an isoenergenic low fat higher carbohydrate (HC) or higher protein (HP) diet while participating in a supervised 30-minute circuit resistance-training program three times per week for 14-weeks. In a randomized and double blind manner, participants ingested supplements containing 1,500 mg/d of glucosamine (as d-glucosamine HCL), 1,200 mg/d of chondroitin sulfate (from chondroitin sulfate sodium), and 900 mg/d of methylsulfonylmethane or a placebo. At 0, 10, and 14-weeks, participants completed a battery of assessments. Data were analyzed by MANOVA with repeated measures.
Participants in both groups experienced significant reductions in body mass (-2.4 ± 3%), fat mass (-6.0 ± 6%), and body fat (-3.5 ± 4%) with no significant changes in fat free mass or resting energy expenditure. Perception of knee pain (-49 ± 39%) and knee stiffness (-42 ± 37%) was decreased while maximal strength (12%), muscular endurance (20%), balance indices (7% to 20%), lipid levels (-8% to -12%), homeostasis model assessment for estimating insulin resistance (-17%), leptin (-30%), and measures of physical functioning (59%), vitality (120%), and social function (66%) were improved in both groups with no differences among groups. Functional aerobic capacity was increased to a greater degree for those in the HP and GCM groups while there were some trends suggesting that supplementation affected perceptions of knee pain (p < 0.08).
Circuit style resistance-training and weight loss improved functional capacity in women with knee OA. The type of diet and dietary supplementation of GCM provided marginal additive benefits.
ClinicalTrials.gov: NCT01271218.
本研究的目的是确定久坐肥胖的膝骨关节炎女性在开始运动和减肥计划后，与高碳水化合物饮食相比，高蛋白质饮食是否可能对身体成分、功能能力和/或健康标志物产生更有益的变化，而高蛋白质饮食可能添加或不添加 GCM 补充剂。
30 名久坐的女性（54±9 岁，163±6cm，88.6±13kg，46.1±3%脂肪，33.3±5kg/m2）被诊断为临床膝骨关节炎，参加了一项为期 14 周的运动和减肥计划。参与者遵循等能量低脂高碳水化合物（HC）或高蛋白（HP）饮食，同时每周三次参加 30 分钟的循环阻力训练计划，持续 14 周。参与者以随机和双盲的方式摄入含有 1500mg/d 氨基葡萄糖（D-氨基葡萄糖盐酸盐）、1200mg/d 硫酸软骨素（来自硫酸软骨素钠）和 900mg/d 甲基磺酰甲烷或安慰剂的补充剂。在 0、10 和 14 周时，参与者完成了一系列评估。数据通过重复测量的 MANOVA 进行分析。
两组参与者的体重（-2.4±3%）、体脂肪（-6.0±6%）和体脂肪（-3.5±4%）均显著降低，而无脂体重或静息能量消耗无显著变化。膝关节疼痛感知（-49±39%）和膝关节僵硬（-42±37%）降低，而最大力量（12%）、肌肉耐力（20%）、平衡指数（7%至 20%）、血脂水平（-8%至-12%）、稳态模型评估估计胰岛素抵抗（-17%）、瘦素（-30%）和身体功能测量（59%）、活力（120%）和社会功能（66%）均在两组中得到改善，组间无差异。HP 和 GCM 组的功能性有氧能力提高程度更大，而补充剂对膝关节疼痛感知的影响存在一些趋势（p<0.08）。
循环式阻力训练和减肥改善了膝骨关节炎女性的功能能力。饮食类型和 GCM 的饮食补充提供了轻微的附加益处。
ClinicalTrials.gov：NCT01271218。
