记忆性CD4 T细胞增强初始CD8 T细胞反应。
Memory CD4 T cells enhance primary CD8 T-cell responses.
作者信息
Krawczyk Connie M, Shen Hao, Pearce Edward J
机构信息
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Room 318 Hill Pavilion, 380 South University Avenue, Philadelphia, PA 19104-4539, USA.
出版信息
Infect Immun. 2007 Jul;75(7):3556-60. doi: 10.1128/IAI.00086-07. Epub 2007 Apr 16.
Abstract
CD4 T-cell help is required for optimal memory CD8 T-cell responses. We have found that engaging preexisting CD4 Th1, but not Th2, memory cells at the time of CD8 T-cell priming results in increased CD8 effector responses to both bacterial and viral pathogens. The enhanced responses are characterized by increased numbers of cytokine-producing, antigen-specific cells. These findings suggest that engaging endogenous memory Th1 cells may increase cellular responses in an immunotherapy or vaccination setting.
摘要
最佳的记忆性CD8 T细胞反应需要CD4 T细胞的辅助。我们发现，在CD8 T细胞启动时激活已有的CD4 Th1记忆细胞而非Th2记忆细胞，会增强CD8效应细胞对细菌和病毒病原体的反应。增强的反应表现为产生细胞因子的抗原特异性细胞数量增加。这些发现表明，激活内源性记忆性Th1细胞可能会在免疫治疗或疫苗接种中增强细胞反应。
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