de la Motte D J, Hall S M, Allt G
Acta Neuropathol. 1975 Dec 19;33(3):257-70. doi: 10.1007/BF00688398.
The response of the perineurium to the following experimental systems was investigated by light and electron microscopy: nerve crush, cold lesion and microinjection of (a) histamine liberator, (b) potassium cyanide, (c) lysophosphatidyl choline (LPC). Where myelin breakdown occurred, lipid globules were seen within Schwann cells, macrophages and also perineurial cells. Where increased vascular permeability occurred, proteinaceous material leaked from endoneurial vessels into the endoneurial space and later appeared between perineurial laminae. It is suggested that the normal homeostatic function of the perineurium is extended in pathology to the removal of protein and lipid debris. In this way the perineurium contributes to the restoration of the normal microenvironment of peripheral nerve fibres.
神经挤压、冷损伤以及显微注射（a）组胺释放剂、（b）氰化钾、（c）溶血磷脂酰胆碱（LPC）。在发生髓鞘崩解的部位，在施万细胞、巨噬细胞以及神经束膜细胞内可见脂质球。在血管通透性增加的部位，蛋白质物质从神经内膜血管渗漏到神经内膜间隙，随后出现在神经束膜板层之间。有人提出，神经束膜的正常稳态功能在病理情况下会扩展到清除蛋白质和脂质碎片。通过这种方式，神经束膜有助于恢复周围神经纤维的正常微环境。
