Givens Melissa L, Gabrysch Jeremy
Department of Emergency Medicine, Madigan Army Medical Center, Tacoma, WA 98431, USA.
Pediatr Emerg Care. 2007 Apr;23(4):234-7. doi: 10.1097/PEC.0b013e31803f5a83.
Bupropion, an atypical antidepressant commonly used for depression and smoking cessation, is well known to cause seizures in both therapeutic use and overdose, but cardiac effects have been reported as minimal, usually sinus tachycardia. We describe an ingestion of bupropion estimated to be greater than 2 g by a 3-year-old boy that resulted in seizures. The child was decontaminated with whole bowel irrigation (WBI), and he experienced aspiration of polyethylene glycol and electrolyte solution used for the WBI. The patient ultimately developed hypotension and bradycardia requiring cardiopulmonary resuscitation due to the effects of the bupropion combined with the complications of WBI. In contrast to previous literature, which showed few clinical effects aside from seizures from ingestion of bupropion by children, our case highlights the dangers of pediatric bupropion ingestion and highlights risks of WBI.
安非他酮是一种常用于治疗抑郁症和帮助戒烟的非典型抗抑郁药，众所周知，无论是在治疗用药还是过量用药时，它都会引发癫痫，但据报道其对心脏的影响极小，通常表现为窦性心动过速。我们描述了一名3岁男孩摄入估计超过2克安非他酮后引发癫痫的病例。该患儿接受了全肠道灌洗（WBI）进行去污处理，期间他吸入了用于WBI的聚乙二醇和电解质溶液。由于安非他酮的作用以及WBI的并发症，该患者最终出现低血压和心动过缓，需要进行心肺复苏。与以往文献中儿童摄入安非他酮除癫痫外几乎没有其他临床影响不同，我们的病例突出了儿童摄入安非他酮的危险性以及WBI的风险。
