McCullough Mona C, Namias Nicholas, Schulman Carl, Gomez Ellie, Manning Ron, Goldberg Seth, Pizano Louis, Ward Gillon C
University ofMiami-Miller School ofMedicine, DeWitt Daughtry Family Department of Surgery, Division of Burns, Miami, Florida, USA.
J Burn Care Res. 2007 May-Jun;28(3):412-20. doi: 10.1097/BCR.0B013E318053D257.
Oxandrolone has been shown to improve lean muscle mass in patients with burns. Hepatic dysfunction is a known side effect of treatment with oxandrolone. The purpose of this study was to examine the incidence of hepatic dysfunction in our series of burn patients receiving oxandrolone. Fourteen patients who received oxandrolone (5 mg, n = 8; 10 mg, n = 6) were identified from our prospectively collected burn database. The records of 61 control patients also were reviewed. Demographics such as age, comorbidities, and burn size were recorded. The incidence of hepatic dysfunction was determined by the presence of abnormal liver function tests. The study and control groups were similar in age and burn size. Two of the eight (25%) oxandrolone patients receiving 5 mg and four of the six (67%) oxandrolone patients receiving 10 mg had evidence of hepatic dysfunction. Twenty six of the 61 (43%) control patients had evidence of hepatic dysfunction (P = NS). There appears no significant increased incidence of hepatic dysfunction in burn patients who received oxandrolone compared to those who did not.
已证实氧雄龙可增加烧伤患者的瘦肌肉量。肝功能障碍是氧雄龙治疗已知的副作用。本研究的目的是调查在我们收治的接受氧雄龙治疗的烧伤患者系列中肝功能障碍的发生率。从我们前瞻性收集的烧伤数据库中确定了14例接受氧雄龙治疗的患者（5毫克组，n = 8；10毫克组，n = 6）。还查阅了61例对照患者的记录。记录了年龄、合并症和烧伤面积等人口统计学数据。通过肝功能检查异常来确定肝功能障碍的发生率。研究组和对照组在年龄和烧伤面积方面相似。接受5毫克氧雄龙治疗的8例患者中有2例（25%）以及接受10毫克氧雄龙治疗的6例患者中有4例（67%）有肝功能障碍的证据。61例对照患者中有26例（43%）有肝功能障碍的证据（P = 无显著性差异）。与未接受氧雄龙治疗的烧伤患者相比，接受氧雄龙治疗的烧伤患者肝功能障碍的发生率似乎没有显著增加。
