Shi Huaikai, Cheer Kenny, Simanainen Ulla, Lesmana Brian, Ma Duncan, Hew Jonathan J, Parungao Roxanne J, Li Zhe, Cooper Mark S, Handelsman David J, Maitz Peter K, Wang Yiwei
Burns Research Group, ANZAC Research Institute, University of Sydney, Concord Hospital, Gate, 3 Hospital road, Concord, NSW 2139, Australia.
Andrology, ANZAC Research Institute, University of Sydney, Concord Hospital, Gate, 3 Hospital road, Concord, NSW 2139, Australia.
Burns Trauma. 2021 Apr 20;9:tkaa046. doi: 10.1093/burnst/tkaa046. eCollection 2021 Jan.
Wound healing is a complex process involving four overlapping phases: haemostasis, inflammation, cell recruitment and matrix remodeling. In mouse models, surgical, pharmacological and genetic approaches targeting androgen actions in skin have shown that androgens increase interleukin-6 and tumor necrosis factor-α production and reduce wound re-epithelization and matrix deposition, retarding cutaneous wound healing. Similarly, clinical studies have shown that cutaneous wound healing is slower in men compared to women. However, in major burn injury, which triggers not only local wound-healing processes but also systemic hypermetabolism, the role of androgens is poorly understood. Recent studies have claimed that a synthetic androgen, oxandrolone, increases protein synthesis, improves lean body mass and shortens length of hospital stay. However, the possible mechanisms by which oxandrolone regulates major burn injury have not been reported. In this review, we summarize the current findings on the roles of androgens in cutaneous and major burn wound healing, as well as androgens as a potential therapeutic treatment option for patients with major burn injuries.
伤口愈合是一个复杂的过程，涉及四个重叠阶段：止血、炎症、细胞募集和基质重塑。在小鼠模型中，针对皮肤中雄激素作用的手术、药理学和遗传学方法表明，雄激素会增加白细胞介素-6和肿瘤坏死因子-α的产生，并减少伤口再上皮化和基质沉积，从而延缓皮肤伤口愈合。同样，临床研究表明，男性的皮肤伤口愈合比女性慢。然而，在不仅引发局部伤口愈合过程，还引发全身代谢亢进的严重烧伤中，雄激素的作用尚不清楚。最近的研究声称，一种合成雄激素氧雄龙可增加蛋白质合成，改善瘦体重并缩短住院时间。然而，氧雄龙调节严重烧伤的可能机制尚未见报道。在这篇综述中，我们总结了目前关于雄激素在皮肤和严重烧伤伤口愈合中的作用的研究结果，以及雄激素作为严重烧伤患者潜在治疗选择的研究结果。
