Department of Pharmacy, Spectrum Health, Grand Rapids, MI, United States.
Department of Surgery, Division of Trauma, Critical Care, and Burn, The Ohio State University Wexner Medical Center, Columbus, OH, United States.
Burns. 2019 Jun;45(4):891-897. doi: 10.1016/j.burns.2018.10.024. Epub 2018 Dec 10.
The benefits of oxandrolone in burn patients has led to its accepted use in the burn care community, however details regarding the most common adverse effect, transaminitis, remains unclear. The purpose of this study was to determine the incidence of transaminitis in patients with burn injury and identify risk factors associated with the development of transaminitis. This single-center, retrospective risk factor analysis compared burn patients on oxandrolone with and without the development of transaminitis, defined as any aspartate aminotransferase or alanine aminotransferase value >100mg/dL. Patient demographics, past medical history, lab values, and burn characteristics were recorded. Overall 28 out of 66 (42%) patients developed transaminitis. The transaminitis group had a significantly higher proportion of other concomitant medications with a transaminitis risk (p=0.045). No significant difference in liver dysfunction or length of stay was observed between the two groups. Oxandrolone induced transaminitis is occurring in patients significantly more frequently than previously reported warranting further research to guide monitoring requirements, use of concomitant medications, and to determine if rechallenging after resolution should be considered.
氧雄龙在烧伤患者中的益处使其在烧伤治疗领域得到了广泛应用，然而，关于最常见的不良反应——转氨血症的细节仍不清楚。本研究旨在确定烧伤患者中转氨酶升高的发生率，并确定与转氨血症发生相关的危险因素。这项单中心回顾性危险因素分析比较了使用氧雄龙的烧伤患者中转氨酶升高（定义为任何天门冬氨酸转氨酶或丙氨酸转氨酶值>100mg/dL）与未升高的患者。记录了患者的人口统计学、既往病史、实验室值和烧伤特征。共有 66 名患者中的 28 名（42%）出现了转氨血症。转氨血症组中同时使用具有转氨血症风险的其他药物的比例显著更高（p=0.045）。两组间肝功能不全或住院时间无显著差异。与之前的报告相比，氧雄龙引起的转氨血症在患者中发生的频率明显更高，这需要进一步的研究来指导监测要求、同时使用药物的情况，并确定是否应在解决后重新考虑使用。
