Bochtler W, Maiers M, Oudshoorn M, Marsh S G E, Raffoux C, Mueller C, Hurley C K
Information Technology and Quality Assurance Working Groups of the World Marrow Donor Association, Leiden, The Netherlands.
Bone Marrow Transplant. 2007 Jun;39(12):737-41. doi: 10.1038/sj.bmt.1705672. Epub 2007 Apr 16.
Since the advent of the European Marrow Donor Information System in the first half of the last decade, fully automated data exchange between registry computer systems has been playing an ever-increasing role in the international search for unrelated donors of blood progenitor cells. This exchange, however, was hampered by different local conventions used to present HLA data and complicated by the need to extend the official WHO nomenclature to accommodate the registries' information systems and to cross-validate HLA data obtained with different methods and/or at different loci. The guidelines presented here have been developed by the World Marrow Donor Association to standardize the nomenclature to be used and the validation checks to be applied in the international electronic exchange of HLA-typing data among unrelated volunteer hematopoietic stem cell donor registries and umbilical cord blood banks. Two reference web sites have been designated to maintain and update the approved HLA nomenclature and all the ancillary information needed by the conventions described here.
自上世纪九十年代上半叶欧洲骨髓捐献者信息系统问世以来，登记处计算机系统之间的全自动数据交换在国际范围内寻找无关造血干细胞捐献者的过程中发挥着越来越重要的作用。然而，这种交换受到用于呈现HLA数据的不同本地惯例的阻碍，并且由于需要扩展世界卫生组织的官方命名法以适应登记处的信息系统，以及对用不同方法和/或在不同位点获得的HLA数据进行交叉验证而变得复杂。本文提出的指南由世界骨髓捐献者协会制定，旨在规范无关志愿造血干细胞捐献者登记处和脐带血库之间在国际电子交换HLA分型数据时所使用的命名法以及应用的验证检查。已指定两个参考网站来维护和更新批准的HLA命名法以及本文所述惯例所需的所有辅助信息。
