Morinaka Brandon I, Skepper Colin K, Molinski Tadeusz F
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
Org Lett. 2007 May 10;9(10):1975-8. doi: 10.1021/ol0705696. Epub 2007 Apr 17.
Seven new brominated ene-yne tetrahydrofurans (THFs), mutafurans A-G, were isolated from the Bahamian sponge Xestospongia muta. The absolute configuration of the natural products was assigned as (5R,8S) by interpretation of the Cotton effect arising from weak perturbation of an ene-yne chromophore by a propargylic THF ring.
从巴哈马海绵Xestospongia muta中分离出了7种新的溴化烯炔四氢呋喃（THF），即变四氢呋喃A - G。通过对炔丙基THF环对烯炔发色团的微弱扰动所产生的科顿效应进行解析，确定了这些天然产物的绝对构型为(5R,8S)。
