Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Chem Phys Lipids. 2011 Oct;164(7):703-6. doi: 10.1016/j.chemphyslip.2011.08.002. Epub 2011 Aug 16.
Four brominated aliphatic hydrocarbons (1-4), including a novel brominated ene-tetrahydrofuran named as mutafuran H (1), and five sterols (5-9) were isolated from the South China Sea sponge Xestospongia testudinaria. The structure of 1 was determined on the basis of NMR ((1)H, (13)C NMR, HSQC, HMBC, (1)H-(1)H COSY, and NOESY), MS, and optical rotation analysis. Known compounds were identified by comparison of their NMR data with those reported in the literature. Compounds 1-4, and 6-9 were evaluated for their toxicity against Artemia salina larvae, and anti-acetylcholinesterase activity.
从南海海绵 Xestospongia testudinaria 中分离得到了四种溴代脂肪烃（1-4），包括一种新型的溴代烯四氢呋喃命名为mutafuran H（1），和五种甾醇（5-9）。1 的结构是基于 NMR ((1)H, (13)C NMR, HSQC, HMBC, (1)H-(1)H COSY 和 NOESY), MS 和旋光分析来确定的。已知化合物通过与文献报道的 NMR 数据进行比较来鉴定。化合物 1-4 和 6-9 被评估了对卤虫幼虫的毒性和乙酰胆碱酯酶抑制活性。
