Gamez Patrick, Mooibroek Tiddo J, Teat Simon J, Reedijk Jan
Leiden Institute of Chemistry, The Netherlands.
Acc Chem Res. 2007 Jun;40(6):435-44. doi: 10.1021/ar7000099. Epub 2007 Apr 18.
Anions are essential species in biological systems and, particularly, in enzyme-substrate recognition. Therefore, the design and preparation of anion receptors is a topical field of supramolecular chemistry. Most host-guest systems successfully developed are based on noncovalent (ionic and hydrogen-bonded) interactions between anions and ammonium-type functionalities or Lewis acid groups. However, since the past 5 years, an alternative route toward the synthesis of efficient anion hosts has emerged, namely, the use of "anion-pi" interactions involving nitrogen-containing electron-deficient aromatic rings, as the result of several favorable theoretical investigations. In this Account, the state of the (new) art in this growing area of anion-binding research is presented and several selected examples from our work and that of other groups will be discussed.
阴离子是生物系统中，尤其是酶-底物识别过程中的重要物种。因此，阴离子受体的设计与制备是超分子化学的一个热门领域。大多数成功开发的主客体体系是基于阴离子与铵型官能团或路易斯酸基团之间的非共价（离子和氢键）相互作用。然而，在过去5年中，由于几项有利的理论研究，出现了一条合成高效阴离子主体的替代途径，即利用含氮缺电子芳香环的“阴离子-π”相互作用。在本综述中，介绍了这一不断发展的阴离子结合研究领域的（新）进展，并将讨论我们团队以及其他团队工作中的几个精选实例。
