双核锌催化的对映选择性氮杂亨利反应。
Dinuclear zinc-catalyzed enantioselective Aza-Henry reaction.
作者信息
Trost Barry M, Lupton David W
机构信息
Department of Chemistry, Stanford University, Stanford, CA 94305-8080, USA.
出版信息
Org Lett. 2007 May 10;9(10):2023-6. doi: 10.1021/ol070618e. Epub 2007 Apr 18.
PMID:17439228
Abstract
The dinuclear zinc catalyst 1a was found to catalyze the addition of nitroalkanes to carbamate-protected imines. This aza-Henry reaction proceeds with high enantioselectivity when various carbamate-protected imines are used. alpha,beta-Unsaturated imines proved to be a particularly useful class of substrate routinely giving the alpha-nitro amine products in high enantiomeric excess.
摘要
发现双核锌催化剂1a能催化硝基烷烃与氨基甲酸酯保护的亚胺的加成反应。当使用各种氨基甲酸酯保护的亚胺时，这种氮杂亨利反应具有高对映选择性。α,β-不饱和亚胺被证明是一类特别有用的底物，通常能以高对映体过量得到α-硝基胺产物。
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