Maremmani Icro, Pani Pier Paolo, Mellini Anna, Pacini Matteo, Marini Giada, Lovrecic Mercedes, Perugi Giulio, Shinderman Marc
Department of Psychiatry-NPB, University of Pisa, Pisa, 56100, Italy.
J Addict Dis. 2007;26(1):61-70. doi: 10.1300/J069v26n01_08.
Alcohol and cocaine abuse result in unsatisfactory treatment outcomes for heroin and illicit opioid addicts engaged in Methadone Maintenance Treatment Programs (MMTPs). This study aims to clarify the impact of MMT, which focuses on cessation of opioid abuse and diminishing psychopathology to acceptable levels (stabilization) on alcohol and cocaine abuse. Of specific interest was whether reduction of polysubstance abuse and associated psychopathological complications diminished illicit opioid abuse and/or increased retention in treatment. Changes in cocaine and alcohol use that occurred in 53 heroin addicts who had been stabilized were monitored. A control group was composed of patients terminated from treatment due to noncompliance with treatment recommendations, poor attendance, or failure to have opioid abuse stabilized, within a year. The association of psychiatric severity with alcohol and cocaine abuse in these methadone maintained patients was assessed. Cessation of illicit opioid abuse and retention in treatment are positively correlated with decrease in alcohol and cocaine abuse and the absence of the psychosocial complications associated with such abuse.
酒精和可卡因滥用会导致参与美沙酮维持治疗项目(MMTPs)的海洛因和非法阿片类药物成瘾者的治疗效果不理想。本研究旨在阐明美沙酮维持治疗(MMT)的影响,该治疗侧重于停止阿片类药物滥用并将精神病理学症状减轻到可接受的水平(稳定状态),以及对酒精和可卡因滥用的影响。特别感兴趣的是,减少多物质滥用及相关的精神病理并发症是否会减少非法阿片类药物滥用和/或提高治疗留存率。对53名已实现稳定状态的海洛因成瘾者的可卡因和酒精使用变化进行了监测。对照组由在一年内因不遵守治疗建议、出勤率低或阿片类药物滥用未得到稳定控制而终止治疗的患者组成。评估了这些接受美沙酮维持治疗的患者中精神疾病严重程度与酒精和可卡因滥用之间的关联。非法阿片类药物滥用的停止和治疗留存率与酒精和可卡因滥用的减少以及与此类滥用相关的社会心理并发症的不存在呈正相关。