Gray Om, McDonnell Gv, Hawkins Sa
Department of Neurology, Royal Victoria Hospital, Belfast, Northern Ireland.
Mult Scler. 2009 Jan;15(1):75-80. doi: 10.1177/1352458508096872. Epub 2008 Oct 1.
To investigate the psychometric properties of the Multiple Sclerosis Impact Scale (MSIS-29) and to assess the relationship between the Kurtzke Expanded Disability Status Scale and the physical and psychological parts of this score.
A population-based study identified cases with definite multiple sclerosis (MS) in the north-east region of Ireland. They were examined and completed the MSIS-29. Cases were classified as mild (Expanded Disability Status Score (EDSS) 0-3.0), moderate (EDSS 3.5-5.5), or severe (6.0-9.5) MS.
The 248 participants (82 male, 166 female) had a mean age of 49.1 years (SD 12.4). EDSS ranged from 0 to 9.5 (median 6.0). Data quality was excellent (0.02% missing data), physical and psychological scores spanned the entire range with low floor and ceiling effects. Internal consistency was high (Cronbach's alpha 0.97 - physical score, 0.93 - psychological score). The convergent validity of the physical impact score of the MSIS-29 with the Kurtzke EDSS was confirmed with a high Spearman's rank coefficient correlation of 0.63 (P = 0.01). Physical impact scores for mild, moderate, and severe disability as were statistically different at 25.9%, 48.0%, and 63.9%, respectively. Mean psychological score was non-significantly higher in the moderately disabled group at 47.4% compared with the severely disabled at 44.3% (P = 0.58).
The MSIS-29 is an acceptable, reliable, and valid method of recording quality of life. A significant relationship between higher physical impact scores of the MSIS-29 and higher Kurtzke EDSS values suggests that is may be of use in clinical trials to monitor progression.
研究多发性硬化症影响量表（MSIS - 29）的心理测量特性，并评估库尔特克扩展残疾状态量表与该评分的身体和心理部分之间的关系。
一项基于人群的研究在爱尔兰东北地区确定了明确的多发性硬化症（MS）病例。对他们进行检查并完成MSIS - 29量表。病例被分类为轻度（扩展残疾状态评分（EDSS）0 - 3.0）、中度（EDSS 3.5 - 5.5）或重度（6.0 - 9.5）MS。
248名参与者（82名男性，166名女性）的平均年龄为49.1岁（标准差12.4）。EDSS范围为0至9.5（中位数6.0）。数据质量极佳（缺失数据0.02%），身体和心理评分涵盖整个范围，地板效应和天花板效应较低。内部一致性较高（克朗巴赫α系数：身体评分0.97，心理评分0.93）。MSIS - 29身体影响评分与库尔特克EDSS的收敛效度通过高斯皮尔曼等级系数相关性0.63得到证实（P = 0.01）。轻度、中度和重度残疾的身体影响评分分别为25.9%、48.0%和63.9%，差异有统计学意义。中度残疾组的平均心理评分为47.4%，与重度残疾组的44.3%相比无显著差异（P = 0.58）。
MSIS - 29是一种可接受、可靠且有效的记录生活质量的方法。MSIS - 29较高的身体影响评分与较高的库尔特克EDSS值之间存在显著关系，表明其可能在临床试验中用于监测疾病进展。
