Iester Michele, Torre Pier Giacomo, Bricola Graziano, Bagnis Alessandro, Calabria Giovanni
Department of Neurological Sciences, Ophthalmology and Genetics, Clinica Oculistica, University of Genoa, Genoa, Italy.
Ophthalmologica. 2007;221(3):180-5. doi: 10.1159/000099298.
To evaluate the retinal blood flow before and after the increase in systemic blood pressure to assess the autoregulation in healthy young subjects.
Twenty eyes of 20 healthy volunteers were examined. The retinal blood flow was assessed by a Heidelberg retina flowmeter (HRF), while the systemic pressure was assessed by a portable electronic sphygmomanometer. Furthermore intraocular pressure (IOP) was always measured by a Goldmann tonometer immediately after HRF assessments. All measurements of physiological and flow parameters were performed with the subjects seated at rest and then immediately after stair climbing.
The IOP decreased significantly after dynamic exercise, while the heart rate and the systemic artery pressure increased significantly. At the baseline, the mean retinal blood flow was 276.8 +/- 80.7 arbitrary units (AU) in the superotemporal area, 243.4 +/- 63.68 AU in the superonasal area, 258.2 +/- 67.37 AU in the inferotemporal area and 243.9 +/- 72.24 AU in the inferonasal area. After dynamic exercise the mean retinal blood flow was 249.8 +/- 86.78 AU in the superotemporal area, 248.7 +/- 63.87 AU in the superonasal area, 245.4 +/- 83.85 AU in the inferotemporal area and 228.8 +/- 62.53 AU in the inferonasal area. No significant change in retinal blood flow was found.
Our data support the hypothesis that in normal subjects autoregulation is sufficient to compensate the increase in blood pressure and maintain a stable retinal blood flow after exercise.
评估健康年轻受试者全身血压升高前后的视网膜血流情况，以评估其自身调节功能。
对20名健康志愿者的20只眼睛进行检查。使用海德堡视网膜血流仪（HRF）评估视网膜血流，同时使用便携式电子血压计评估全身血压。此外，在每次HRF评估后，立即使用Goldmann眼压计测量眼压。所有生理和血流参数的测量均在受试者静息坐位时进行，然后在爬楼梯后立即进行。
动态运动后眼压显著降低，而心率和全身动脉压显著升高。基线时，颞上区域平均视网膜血流为276.8±80.7任意单位（AU），鼻上区域为243.4±63.68 AU，颞下区域为258.2±67.37 AU，鼻下区域为243.9±72.24 AU。动态运动后，颞上区域平均视网膜血流为249.8±86.78 AU，鼻上区域为248.7±63.87 AU，颞下区域为245.4±83.85 AU，鼻下区域为228.8±62.53 AU。未发现视网膜血流有显著变化。
我们的数据支持以下假设，即在正常受试者中，自身调节足以补偿运动后血压的升高并维持稳定的视网膜血流。
