Nussbaumer M, Donath L, Fischer M, Schäfer J, Faude O, Zahner L, Schmidt-Trucksäss A, Hanssen H
Department of Sport, Exercise and Health, Division of Sports and Exercise Medicine, Medical Faculty, University of Basel, Birsstrasse 320B, 4052, Basel, Switzerland.
Age (Dordr). 2014 Jun;36(3):9650. doi: 10.1007/s11357-014-9650-3. Epub 2014 Apr 12.
Alterations of retinal vessel diameters are associated with increased cardiovascular risk. We aimed to investigate changes in retinal vessel diameters in response to acute dynamic exercise of different intensities and whether these changes are age dependent. Seventeen healthy seniors (median (IQR) age 68 (65, 69) years) and 15 healthy young adults (median (IQR) age 26 (25, 28) years) first performed a maximal treadmill test (MTT) followed by a submaximal treadmill test (SMTT) and a resting control condition in randomised order. Central retinal arteriolar (CRAE) and central retinal venular (CRVE) diameter equivalents were measured before as well as 5 (t5) and 40 (t40) minutes after exercise cessation using a static retinal vessel analyser. Both exercise intensities induced a significant dilatation in CRAE and CRVE at t5 compared to the control condition (P < 0.001). At t40, the mean increase in CRAE and CRVE was greater for MTT compared to that for SMTT (CRAE 1.7 μm (95 % confidence interval (CI) -0.1, 3.6; P = 0.061); CRVE 2.2 μm (95 % CI 0.4, 4.1; P = 0.019)). However, the estimated difference at t5 between seniors and young adults in their response to MTT compared to SMTT was 5.3 μm (95 % CI 2.0, 8.5; P = 0.002) for CRAE and 4.1 μm (95 % CI -0.4, 8.6; P = 0.076) for CRVE. Wider arteries and veins after maximal versus submaximal exercise for seniors compared to young adults suggest that myogenic vasoconstriction in response to exhaustive exercise may be reduced in seniors. Age-related loss of vascular reactivity has clinical implications since the arteriolar vasoconstriction protects the retinal capillary bed from intraluminal pressure peaks.
视网膜血管直径的改变与心血管疾病风险增加有关。我们旨在研究不同强度的急性动态运动对视网膜血管直径的影响，以及这些变化是否与年龄相关。17名健康老年人（年龄中位数（四分位间距）为68（65,69）岁）和15名健康年轻人（年龄中位数（四分位间距）为26（25,28）岁）首先进行了最大运动平板试验（MTT），然后依次进行了次最大运动平板试验（SMTT）和静息对照试验，试验顺序随机。使用静态视网膜血管分析仪在运动停止前以及停止后5（t5）和40（t40）分钟测量视网膜中央动脉（CRAE）和视网膜中央静脉（CRVE）的等效直径。与对照条件相比，两种运动强度在t5时均导致CRAE和CRVE显著扩张（P < 0.001）。在t40时，MTT组CRAE和CRVE的平均增加幅度大于SMTT组（CRAE增加1.7μm（95%置信区间（CI）-0.1,3.6；P = 0.061）；CRVE增加2.2μm（95%CI 0.4,4.1；P = 0.019））。然而，老年人与年轻人在MTT与SMTT反应中t5时的估计差异，CRAE为5.3μm（95%CI 2.0,8.5；P = 0.002），CRVE为4.1μm（95%CI -0.4,8.6；P = 0.076）。与年轻人相比，老年人在最大运动与次最大运动后动脉和静脉更宽，这表明老年人对力竭运动的肌源性血管收缩可能减弱。血管反应性的年龄相关丧失具有临床意义，因为小动脉血管收缩可保护视网膜毛细血管床免受管腔内压力峰值的影响。
