Glufka R, Maeba P
Department of Microbiology, University of Manitoba, Winnipeg, Canada.
J Bacteriol. 1991 Dec;173(24):7988-91. doi: 10.1128/jb.173.24.7988-7991.1991.
VGP is a major cell-surface glycoprotein present in vegetative cells of Myxococcus xanthus. Serological assays indicated that this protein was released from cells and accumulated in the medium during development, i.e., aggregation, fruiting body formation, and myxosporulation. Cells induced to form spores in the absence of aggregation retained VGP, indicating that loss of VGP was associated with developmental aggregation rather than myxosporulation. Anti-VGP antibodies inhibited vegetative cell gliding, suggesting the protein may also be required for motility.
VGP是一种存在于黄色粘球菌营养细胞中的主要细胞表面糖蛋白。血清学分析表明，这种蛋白质在发育过程中，即聚集、子实体形成和粘孢子形成过程中从细胞中释放出来并积累在培养基中。在没有聚集的情况下被诱导形成孢子的细胞保留了VGP，这表明VGP的丧失与发育性聚集而非粘孢子形成有关。抗VGP抗体抑制营养细胞的滑动，表明该蛋白质可能也是运动所必需的。
