Lönnroos E, Kautiainen H, Karppi P, Hartikainen S, Kiviranta I, Sulkava R
Department of Geriatrics, Central Finland Hospital, Jyväskylä, Finland.
Osteoporos Int. 2007 Sep;18(9):1279-85. doi: 10.1007/s00198-007-0375-3. Epub 2007 Apr 18.
We studied the incidence of second hip fractures and medication use among the patients with sequential hip fractures. This study shows that the incidence rate of second hip fractures is higher than that of the first hip fractures. Improvement in osteoporosis care and a more critical policy for prescription of psychotropic drugs are needed.
This study had two goals: (1) to determine incidence of second hip fractures; (2) to describe changes in pharmacotherapy between first and second hip fractures, especially the use of those psychotropics which increase the risk of falling and also pharmacotherapy for osteoporosis.
The residents of Central Finland Health Care District who had sustained a hip fracture in 2002-2003 were followed up for subsequent hip fractures until 2006. Hip fracture patients were identified and clinical data were obtained by using hospital registers and medical records.
Five hundred and one persons aged >or= 60 years suffered their first hip fracture in 2002-2003. During the follow-up of 936 person-years, 34 second hip fractures occurred. The cumulative incidence of second hip fractures was 5.08% (95% CI: 3.30 to 7.78) at one year, and 8.11% (95% CI: 5.73 to 11.43) at two years after the first fracture. The second part of this study investigated 75 patients with two non-contemporaneous hip fractures. Between the first and second fractures, the number of psychotropic drug users rose from 27 (36%) to 44 (59%). At the time of second hip fracture, osteoporosis had been diagnosed in 17 (23%) patients only. Twelve (16%) patients used bisphosphonates or calcitonin, 15 (20%) used calcium and 9 (12%) vitamin D supplements.
There is a high incidence of second hip fractures. Secondary prevention of hip fractures needs to be improved. In addition to adequate treatment for osteoporosis, more attention should be directed toward appropriate use of psychotropic drugs.
我们研究了连续性髋部骨折患者中二次髋部骨折的发生率及药物使用情况。本研究表明,二次髋部骨折的发生率高于首次髋部骨折。需要改善骨质疏松症护理,并对精神药物处方采取更严格的政策。
本研究有两个目标:(1)确定二次髋部骨折的发生率;(2)描述首次和二次髋部骨折之间药物治疗的变化,特别是增加跌倒风险的精神药物的使用以及骨质疏松症的药物治疗。
对2002年至2003年期间在芬兰中部医疗保健区发生髋部骨折的居民进行随访,直至2006年观察其后是否发生二次髋部骨折。通过医院登记册和病历识别髋部骨折患者并获取临床数据。
2002年至2003年期间,501名年龄≥60岁的患者首次发生髋部骨折。在936人年的随访期间,发生了34例二次髋部骨折。首次骨折后1年,二次髋部骨折的累积发生率为5.08%(95%置信区间:3.30至7.78),2年时为8.11%(95%置信区间:5.73至11.43)。本研究的第二部分调查了75例非同期发生两次髋部骨折的患者。在首次和二次骨折之间,使用精神药物的患者人数从27例(36%)增至44例(59%)。在二次髋部骨折时,仅17例(23%)患者被诊断患有骨质疏松症。12例(16%)患者使用双膦酸盐或降钙素,15例(20%)使用钙,9例(12%)使用维生素D补充剂。
二次髋部骨折的发生率很高。髋部骨折的二级预防需要改善。除了对骨质疏松症进行充分治疗外,应更加关注精神药物的合理使用。