Ballesio L, Maggi C, Savelli S, Angeletti M, Rabuffi P, Manganaro L, Porfiri L M
Dipartimento di Scienze Radiologiche, Policlinico Umberto I, Viale del Policlinico 155, I-00161 Rome, Italy.
Radiol Med. 2007 Apr;112(3):354-65. doi: 10.1007/s11547-007-0146-4. Epub 2007 Apr 20.
The purpose of this study was to evaluate the adjunctive diagnostic value of breast ultrasonography (US) in the study of benign ductal breast disease.
Fifty-two patients underwent US examinations for bloody nipple discharge, palpable retroareolar masses, retroareolar opacities or ductal pattern on mammography. US enabled visualisation of mammary-duct ectasia (simple or pseudocystic, retroareolar and/or peripheral) and focal masses (endoluminal or periductal, with ill-defined or regular margins). All patients with nipple discharge underwent cytological evaluation. After the US examination, all focal masses with ill-defined margins underwent fine-needle aspiration biopsy (FNAB), if necessary. The benign alterations were followed up.
In 38/52 cases, US diagnosed mammary-duct ectasia and in 30/52 cases, the presence of focal masses (mean size 7 mm). In the nine women who underwent biopsy, histopathological evaluation diagnosed five solitary papillomas, one solitary papilloma with a focal area of ductal carcinoma in situ (DCIS), two multiple papillomas of the nipple and one papillomatosis.
High-frequency US plays an important role in the detection of benign ductal disease both for the diagnosis and classification of focal masses and mammary-duct ectasia. US can be used as a complementary imaging method to galactography or as a valuable alternative when galactography is not available.
本研究旨在评估乳腺超声检查（US）在乳腺良性导管疾病研究中的辅助诊断价值。
52例患者因乳头血性溢液、乳晕后可触及肿块、乳晕后密度增高或乳腺钼靶检查显示导管影像而接受超声检查。超声能够显示乳腺导管扩张（单纯性或假性囊肿性，乳晕后和/或外周性）及局灶性肿块（管腔内或导管周围性，边界不清或规则）。所有乳头溢液患者均接受了细胞学评估。超声检查后，所有边界不清的局灶性肿块必要时均接受了细针穿刺活检（FNAB）。对良性病变进行了随访。
52例患者中，38例超声诊断为乳腺导管扩张，30例显示存在局灶性肿块（平均大小7mm）。9例接受活检的女性中，组织病理学评估诊断出5例孤立性乳头状瘤、1例伴有局灶性导管原位癌（DCIS）的孤立性乳头状瘤、2例乳头多发性乳头状瘤和1例乳头状瘤病。
高频超声在乳腺良性导管疾病的检测中发挥着重要作用，无论是对局灶性肿块还是乳腺导管扩张的诊断及分类。超声可作为乳腺导管造影的补充成像方法，或在无法进行乳腺导管造影时作为有价值的替代方法。
