Kröncke Klaus-D
Institute of Biochemistry and Molecular Biology I, Heinrich-Heine-University of Düsseldorf, Universitätsstr.1, D-40225, Düsseldorf, Germany.
Arch Biochem Biophys. 2007 Jul 15;463(2):183-7. doi: 10.1016/j.abb.2007.03.008. Epub 2007 Apr 2.
Various stressful conditions like oxidative or nitrosative stress, heavy metal load or thiol-modifying compounds have been shown to disturb the intracellular zinc homeostasis leading to increasing concentrations of free zinc within the cytoplasm or nuclei of cells. However, much less is known about the consequences of a disturbed intracellular Zn2+ homeostasis under these conditions. Current knowledge is reviewed here.
各种应激条件，如氧化应激或亚硝化应激、重金属负荷或硫醇修饰化合物，已被证明会扰乱细胞内锌稳态，导致细胞胞质或细胞核内游离锌浓度增加。然而，在这些条件下，对于细胞内Zn2+稳态紊乱的后果知之甚少。本文对现有知识进行了综述。
