环孢素治疗外阴硬化性苔藓的开放标签试验。
Open-label trial of cyclosporine for vulvar lichen sclerosus.
作者信息
Bulbul Baskan Emel, Turan Hakan, Tunali Sukran, Toker Semra Cikman, Saricaoglu Hayriye
机构信息
Uludag University Medical Faculty, Department of Dermatology, Gorukle 16059, Bursa, Turkey.
出版信息
J Am Acad Dermatol. 2007 Aug;57(2):276-8. doi: 10.1016/j.jaad.2007.03.006. Epub 2007 Apr 17.
BACKGROUND
Lichen sclerosus (LS) is a chronic inflammatory disease of skin and mucosal surfaces which is generally difficult to treat.
OBJECTIVE
We evaluated the efficacy of oral cyclosporine in refractory vulvar LS.
METHODS
Five patients with refractory vulvar LS were treated with oral cyclosporine (3-4 mg/kg/d) for 3 months. They were followed up on a monthly basis.
RESULTS
At the end of the treatment, the mean total symptom score regressed significantly and clinical findings such as erythema and erosion showed marked improvement. Mild adverse effects were seen in 3 patients.
LIMITATIONS
The patients did not give consent to rebiopsy at the end of the treatment.
CONCLUSION
Moderate dose of oral cyclosporine could be an effective alternative in the treatment of refractory vulvar LS.
背景
硬化性苔藓（LS）是一种皮肤和黏膜表面的慢性炎症性疾病，通常难以治疗。
目的
我们评估了口服环孢素治疗难治性外阴LS的疗效。
方法
5例难治性外阴LS患者接受口服环孢素（3 - 4mg/kg/d）治疗3个月。每月进行随访。
结果
治疗结束时，平均总症状评分显著下降，红斑和糜烂等临床症状有明显改善。3例患者出现轻度不良反应。
局限性
患者在治疗结束时未同意再次活检。
结论
中等剂量口服环孢素可能是治疗难治性外阴LS的有效替代方法。
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