Patrizi Annalisa, Gurioli C, Medri M, Neri I
Dermatology, Department of Internal Medicine, Oldness and Nephrologic Diseases, University of Bologna, Bologna, Italy.
Pediatr Dermatol. 2010 Jan-Feb;27(1):101-3. doi: 10.1111/j.1525-1470.2009.01050.x.
Lichen sclerosus (LS) shows a predilection for the genital area and occurs mostly in postmenopausal women and in prepubertal girls. We conducted a retrospective review of 15 young girls whit genital LS with onset before the menarcheal age and treated with topical clobetasol propionate 0.05%. The mean duration of follow-up was 4.7 years with relapses in nine patients after approximately 1 year from the first clearing. At the end of the study we observed that (i) potent topical steroids are safe and effective in childhood, (ii) an early aggressive treatment gives the best therapeutic response, (iii) one follow-up visit a year is required to monitor for relapsing.
硬化性苔藓（LS）好发于生殖器部位，多见于绝经后女性和青春期前女孩。我们对15例初潮前发病并接受0.05%丙酸氯倍他索局部治疗的年轻生殖器LS女孩进行了回顾性研究。平均随访时间为4.7年，9例患者在首次皮损消退约1年后复发。研究结束时我们观察到：（i）强效局部类固醇在儿童期安全有效；（ii）早期积极治疗可获得最佳治疗反应；（iii）需要每年进行一次随访以监测复发情况。
