Moum Truls, Olsaker Ingrid, Hopp Petter, Moldal Torfinn, Valheim Mette, Moum Torbjørn, Benestad Sylvie L
Norwegian School of Veterinary Science, Department of Production Animal Clinical Sciences, Kyrkjevegen 332-334, N-4325 Sandnes, Norway.
Norwegian School of Veterinary Science, Department of Basic Sciences and Aquatic Medicine, PO Box 8146 Dep., N-0033 Oslo, Norway.
J Gen Virol. 2005 Jan;86(Pt 1):231-235. doi: 10.1099/vir.0.80437-0.
Until June 2004, thirty-eight scrapie cases with unusual features, designated Nor98, have been diagnosed in Norway. This study investigated the distribution of PrP genotypes among Nor98 cases, their flock-mates and a random sample of Norwegian slaughtered sheep. The PrP genotype distribution of Nor98 cases differed markedly from that of previous cases of classical scrapie. A leucine/phenylalanine polymorphism at codon 141 with hitherto unknown significance to scrapie was strongly associated with Nor98 cases. Twenty of 38 (52.6 %) cases were either homozygous or heterozygous for phenylalanine at codon 141. In contrast, this allele was present in only 10.5 % of the flock-mates and 4.5 % of the random sample of slaughtered sheep. Moreover, the H(154) allele was represented in 24 of 38 (63.2 %) of Nor98 cases, as opposed to 27.0 % of Nor98 flock-mates and 17.0 % of the slaughtered sheep.
截至2004年6月，挪威已诊断出38例具有异常特征的羊瘙痒病病例，称为Nor98。本研究调查了Nor98病例、其同群羊以及挪威屠宰羊随机样本中PrP基因型的分布情况。Nor98病例的PrP基因型分布与先前经典羊瘙痒病病例的分布明显不同。密码子141处的亮氨酸/苯丙氨酸多态性，此前对羊瘙痒病意义未知，与Nor98病例密切相关。38例病例中有20例（52.6%）在密码子141处为苯丙氨酸纯合子或杂合子。相比之下，该等位基因在同群羊中仅占10.5%，在屠宰羊随机样本中占4.5%。此外，H(154)等位基因在38例Nor98病例中的24例（63.2%）中出现，而在Nor98同群羊中占27.0%，在屠宰羊中占17.0%。
