Harsch I A, Bergmann T, Koebnick C, Wiedmann R, Ruderich F, Hahn E G, Konturek P C
Medical Department I, Division of Endocrinology and Metabolism, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
J Physiol Pharmacol. 2007 Mar;58 Suppl 1:65-76.
The aim of the study was to investigate, whether the degree of metabolic risk factors for atherosclerotic complications in a very rare kind of obesity, the Multiple Symmetrical Lipomatosis, also known as the Launois-Bensaude Syndrome (LBS), are comparable or different from "simple" truncal obesity. 10 patients with LBS (Body mass index 34.4 +/- 1.8 kg/m(2), age: 62 +/- 3 yrs) were compared with 19 BMI - matched patients with "simple" truncal obesity and obstructive sleep apnoea syndrome (OSAS) and 20 BMI- matched patients with "simple" truncal obesity without OSAS. Markers of subclinical inflammation and thrombocyte activation (sCD62p = soluble p-selectin, highly sensitive C-Reactive protein = CRP, Interleukin-6 = IL-6, ICAM-1 = Intracellular Adhesion Molecule-1, Vascular Cell Adhesion Molecule = VCAM -1, leptin), as well as adiponectin and resistin were studied. The prevalence of atherogenic risk factors as hypertension (80%), type 2 diabetes (30%), OSAS (50%), smoking (30%) and alcohol abuse (80%) was high in the (obese) LBS group. The markers of subclinical inflammation and thrombocyte activation showed an indifferent picture with lower levels of circulating IL-6 and sCD62p, comparable CRP and higher ICAM-1 and VCAM-1 than in controls. Leptin and adiponectin were higher than in controls. However, the accumulation of "classic" cardiovascular risk factors in the LBS group was well reflected by the presence of symptomatic cardiovascular disease in 3 of the 10 LBS patients, putting LBS patients - if obese - at an atherosclerotic risk at least comparable to obese persons.
本研究的目的是调查一种非常罕见的肥胖症——多发性对称性脂肪瘤病（也称为洛努瓦-本索德综合征，LBS）中动脉粥样硬化并发症的代谢风险因素程度，是否与“单纯”腹型肥胖相当或不同。将10例LBS患者（体重指数34.4±1.8kg/m²，年龄：62±3岁）与19例体重指数匹配的“单纯”腹型肥胖合并阻塞性睡眠呼吸暂停综合征（OSAS）患者以及20例体重指数匹配的无OSAS的“单纯”腹型肥胖患者进行比较。研究了亚临床炎症和血小板活化的标志物（可溶性p-选择素sCD62p、高敏C反应蛋白CRP、白细胞介素-6 IL-6、细胞间黏附分子-1 ICAM-1、血管细胞黏附分子VCAM-1、瘦素），以及脂联素和抵抗素。（肥胖的）LBS组中动脉粥样硬化危险因素的患病率较高，如高血压（80%）、2型糖尿病（30%）、OSAS（50%）、吸烟（30%）和酗酒（80%）。亚临床炎症和血小板活化的标志物呈现出不同的情况，循环中的IL-6和sCD62p水平较低，CRP水平相当，ICAM-1和VCAM-1水平高于对照组。瘦素和脂联素高于对照组。然而，10例LBS患者中有3例出现有症状的心血管疾病，很好地反映了LBS组中“经典”心血管危险因素的积累，这使得LBS患者（如果肥胖）的动脉粥样硬化风险至少与肥胖者相当。
