Division of Nephrology and Hypertension, 1st Department of Internal Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Sleep Laboratory, "Aghios Pavlos" General Hospital, Thessaloniki, Greece.
Sleep Breath. 2021 Sep;25(3):1301-1307. doi: 10.1007/s11325-020-02232-9. Epub 2020 Oct 26.
Obstructive sleep apnea (OSA) has been related to vascular inflammation and production of endothelial cell adhesion molecules (CAMs). We aimed to determine night-morning variation of CAMs in patients with OSA compared to controls and the effect of one-night continuous positive airway pressure (CPAP) treatment on them.
Nonsmoking men went through a full-attended polysomnography (PSG) study. Participants with moderate to severe OSA went through another PSG study while being treated with CPAP. Participants who did not have OSA composed the control group. Serum levels of intercellular adhesion molecule-1 (ICAM-1), vascular adhesion molecule-1 (VCAM-1), and E-selectin were measured before and after sleep on both nights.
Of 30 men, 20 had moderate to severe OSA while 10 did not. Night and morning ICAM-1 levels of patients with OSA were significantly higher than controls (p = 0.002 and p < 0.0001 respectively), while both night and morning VCAM-1 and E-selectin levels were not. Morning ICAM-1 levels of controls were significantly lower than night levels (p = 0.031), while morning ICAM-1, VCAM-1, and E-selectin levels of patients with OSA and morning VCAM-1 and E-selectin levels of controls were not. After CPAP treatment, the morning ICAM-1 levels, but not VCAM-1 levels, of patients with OSA were significantly lower than night levels (p = 0.006) and E-selectin levels showed a tendency for reduction (p = 0.06).
OSA is associated with elevated night and morning ICAM-1 levels in adult men with OSA. Even one night of CPAP treatment restores the normal night-morning variation of ICAM-1 levels and may have an effect on E-selectin levels, as well.
阻塞性睡眠呼吸暂停（OSA）与血管炎症和内皮细胞黏附分子（CAMs）的产生有关。我们旨在确定与对照组相比，OSA 患者的 CAMs 在夜间至清晨的变化，以及一夜持续气道正压通气（CPAP）治疗对它们的影响。
非吸烟男性接受了全面的多导睡眠图（PSG）研究。患有中重度 OSA 的参与者在接受 CPAP 治疗的同时接受了另一项 PSG 研究。没有 OSA 的参与者组成对照组。在两晚的睡眠前后测量血清细胞间黏附分子-1（ICAM-1）、血管黏附分子-1（VCAM-1）和 E-选择素水平。
30 名男性中，20 名患有中重度 OSA，10 名没有。OSA 患者的夜间和清晨 ICAM-1 水平明显高于对照组（p = 0.002 和 p < 0.0001），而夜间和清晨 VCAM-1 和 E-选择素水平则没有。对照组的清晨 ICAM-1 水平明显低于夜间水平（p = 0.031），而 OSA 患者的清晨 ICAM-1、VCAM-1 和 E-选择素水平以及对照组的清晨 VCAM-1 和 E-选择素水平则没有。CPAP 治疗后，OSA 患者的清晨 ICAM-1 水平，而不是 VCAM-1 水平，明显低于夜间水平（p = 0.006），E-选择素水平也呈下降趋势（p = 0.06）。
OSA 与成年男性 OSA 患者夜间和清晨 ICAM-1 水平升高有关。即使一夜 CPAP 治疗也能恢复 ICAM-1 水平的正常夜间至清晨变化，并且可能对 E-选择素水平也有影响。
