Lehrer S B, Horner W E, Menon P K, Oliver J, Hauck P
Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112.
J Allergy Clin Immunol. 1991 Dec;88(6):895-901. doi: 10.1016/0091-6749(91)90246-k.
Previous investigations demonstrated that cockroach whole bodies and feces are important sources of allergens in the induction/exacerbation of bronchial asthma. The current study investigated different cockroach source materials, commercial extracts, and house dust extracts for cockroach allergenic activity. In general, extracts from four different sources of either American or German cockroaches contained similar amounts of allergenic activity by RAST inhibition. Three commercial American cockroach extracts compared by RAST inhibition had similar allergenic activity on an equal protein basis. Skin test results correlated house dust reactivity to both commercial and inhouse cockroach wholebody extracts and to fecal extracts. Six different samples of house dust obtained from vacuum cleaners in the New Orleans area and three commercially obtained house dust extracts contained varying quantities of cockroach allergenic activity by RAST inhibition. These studies demonstrate that commercial cockroach extracts vary in allergenic activity and that all house dust extracts tested contain cockroach allergens.
先前的研究表明，蟑螂的整个身体和粪便都是诱发/加重支气管哮喘的重要过敏原来源。当前的研究调查了不同的蟑螂源材料、商业提取物和室内灰尘提取物的蟑螂致敏活性。总体而言，通过放射性过敏原吸附试验（RAST）抑制法检测，来自四种不同来源的美洲蟑螂或德国蟑螂的提取物所含的致敏活性量相似。通过RAST抑制法比较的三种商业美洲蟑螂提取物在等量蛋白质基础上具有相似的致敏活性。皮肤试验结果表明，室内灰尘对商业和自制蟑螂全身提取物以及粪便提取物的反应性相关。通过RAST抑制法检测，从新奥尔良地区的吸尘器中获得的六个不同的室内灰尘样本以及三种商业获得的室内灰尘提取物含有不同量的蟑螂致敏活性。这些研究表明，商业蟑螂提取物的致敏活性各不相同，并且所有测试的室内灰尘提取物都含有蟑螂过敏原。
