Glick R, Harrison W, Endicott J, McGrath P, Quitkin F M
J Am Med Womens Assoc (1972). 1991 Nov-Dec;46(6):182-5.
Although research has established a strong association between premenstrual dysphoric symptoms and depression, there is little data on the effect of antidepressents on premenstrual symptoms. This study compared the efficacy of three treatments--imipramine, phenelzine, and placebo--on the premenstrual symptoms of women with atypical depression who had responded to treatment for their depressive symptoms. The Premenstrual Assessment Form (PAF) was used to rate the type and degree of premenstrual symptomatology. After 12 weeks, at least two-thirds of the women on active medication showed improvement on most measures of premenstrual symptoms to the degree that they had essentially no premenstrual problems after treatment. By comparison, only half of a group of women who had responded to placebo treatment of 6 weeks duration showed such improvement.
尽管研究已证实经前烦躁症状与抑郁症之间存在紧密关联，但关于抗抑郁药对经前症状影响的数据却很少。本研究比较了三种治疗方法——丙咪嗪、苯乙肼和安慰剂——对非典型抑郁症女性经前症状的疗效，这些女性的抑郁症状已对治疗产生反应。经前评估表（PAF）用于评定经前症状的类型和程度。12周后，至少三分之二服用活性药物的女性在大多数经前症状测量指标上有所改善，以至于治疗后她们基本没有经前问题。相比之下，在为期6周的安慰剂治疗中有反应的一组女性中，只有一半表现出这样的改善。
