Mulvey Robert E, Mongin Florence, Uchiyama Masanobu, Kondo Yoshinori
WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, G11XL, UK.
Angew Chem Int Ed Engl. 2007;46(21):3802-24. doi: 10.1002/anie.200604369.
Historically, single-metal organometallic species such as organolithium compounds have been the reagents of choice in synthetic organic chemistry for performing deprotonation reactions. Over the past few years, a complementary new class of metalating agents has started to emerge. Owing to a variable central metal (magnesium, zinc, or aluminum), variable ligands (both in their nature and number), and a variable second metallic center (an alkali metal such as lithium or sodium), "ate" complexes are highly versatile bases that exhibit a synergic chemistry which cannot be replicated by the homometallic magnesium, zinc, or aluminum compounds on their own. Deprotonation accomplished by using these organometallic ate complexes has opened up new perspectives in organic chemistry with unprecedented reactivities and sometimes unusual and unpredictable regioselectivities.
从历史上看，单金属有机金属物种，如有机锂化合物，一直是合成有机化学中进行去质子化反应的首选试剂。在过去几年中，一类互补的新型金属化试剂开始出现。由于中心金属（镁、锌或铝）可变、配体（性质和数量）可变以及第二个金属中心（锂或钠等碱金属）可变，“ate”配合物是高度通用的碱，表现出一种协同化学性质，这是同金属的镁、锌或铝化合物自身无法复制的。使用这些有机金属ate配合物实现的去质子化反应在有机化学中开辟了新的前景，具有前所未有的反应活性，有时还具有不寻常和不可预测的区域选择性。
