Flores A C, Marcos C Y, Paladino N, Arruvito L, Williams F, Middleton D, Fainboim L
Laboratorio de Inmunogenética, Hospital de Clínicas, Buenos Aires, Argentina.
Tissue Antigens. 2007 Apr;69 Suppl 1:112-3. doi: 10.1111/j.1399-0039.2006.762_8.x.
The present study demonstrated that patients who have recurrent spontaneous abortions (RSA) presented a decreased number of killer immunoglobulin-like inhibitory receptors (KIR), in particular KIR2DL2. The KIR AA genotype was found increased in comparison with controls. Individuals AA will also be homozygous for 2DL3, which in contrast to 2DL2, show a weaker interaction with C1 ligands and therefore a weaker inhibition. The present study might support that in RSA patients, the balance between inhibitory and activating receptors present in natural killer cells is inclined toward an activating state that may contribute to pregnancy loss.
本研究表明，复发性自然流产（RSA）患者的杀伤细胞免疫球蛋白样抑制性受体（KIR）数量减少，尤其是KIR2DL2。与对照组相比，发现KIR AA基因型有所增加。AA个体对于2DL3也将是纯合的，与2DL2相比，2DL3与C1配体的相互作用较弱，因此抑制作用也较弱。本研究可能支持，在RSA患者中，自然杀伤细胞中抑制性和激活性受体之间的平衡倾向于激活性状态，这可能导致妊娠丢失。
