Azadbakht Leila, Mirmiran Parvin, Hedayati Mehdi, Esmaillzadeh Ahmad, Shiva Nilufar, Azizi Fereidoun
Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
Br J Nutr. 2007 Jul;98(1):134-9. doi: 10.1017/S0007114507657857. Epub 2007 Apr 20.
The objective was to determine the effects of the National Cholesterol Education Program (NCEP) step II diet on LDL and HDL particle size in dyslipidaemic adolescents. Forty-four dyslipidaemic adolescents, aged 10-18 years, participated in this case-control study. The control diet was a diet similar to what most Tehranian adolescents eat. NCEP step II diet was a diet with 30 % of energy as total fat, less than 7 % saturated fat, less than 200 mg cholesterol/d, less than 15 % of energy as MUFA and less than 10 % as PUFA. Lipoprotein particle size was the major outcome variable, which was measured after 3 months of intervention. Comparison was made by the repeated measurement ANOVA. The mean BMI was 26.3 (sd 4.2) kg/m2. There were no significant changes in weight or physical activity in the two groups during the study. The NCEP diet resulted in higher reduction in total cholesterol ( - 13 (sd 4) v. - 2 (sd 0.3) mg/dl, P < 0.001) and LDL ( - 9 (sd 2) v. 3 (sd 0.6) mg/dl, P < 0.01), and higher increase in size of the LDL (1.7 (sd 0.4) v. 0.1 (sd 0.4) nanometer, P < 0.001). HDL particle size did not change significantly. NCEP step II diet had a favourable effect on the LDL particle size. The related mechanism needs to be studied in future experimental designs.
目的是确定国家胆固醇教育计划（NCEP）第二步饮食对血脂异常青少年低密度脂蛋白（LDL）和高密度脂蛋白（HDL）颗粒大小的影响。44名年龄在10 - 18岁的血脂异常青少年参与了这项病例对照研究。对照饮食是一种类似于大多数德黑兰青少年所食用的饮食。NCEP第二步饮食是一种总脂肪占能量30%、饱和脂肪低于7%、胆固醇每日摄入量低于200毫克、单不饱和脂肪酸（MUFA）占能量低于15%且多不饱和脂肪酸（PUFA）占能量低于10%的饮食。脂蛋白颗粒大小是主要的结局变量，在干预3个月后进行测量。采用重复测量方差分析进行比较。平均体重指数（BMI）为26.3（标准差4.2）kg/m²。研究期间两组的体重或身体活动均无显著变化。NCEP饮食使总胆固醇降低幅度更大（-13（标准差4）对-2（标准差0.3）mg/dl，P < 0.001）以及LDL降低幅度更大（-9（标准差2）对3（标准差0.6）mg/dl，P < 0.01），并且LDL颗粒大小增加幅度更大（1.7（标准差0.4）对0.1（标准差0.4）纳米，P < 0.001）。HDL颗粒大小无显著变化。NCEP第二步饮食对LDL颗粒大小有有利影响。相关机制需要在未来的实验设计中进行研究。
