通过酪氨酸取代将自身肽序列转化为Kd限制的新抗原。
Conversion of a self peptide sequence into a Kd-restricted neo-antigen by a Tyr substitution.
作者信息
Healy F, Drouet C, Romero P, Jaulin C, Maryanski J L
机构信息
Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland.
出版信息
J Exp Med. 1991 Dec 1;174(6):1657-60. doi: 10.1084/jem.174.6.1657.
Abstract
We have previously found that a Tyr residue was critical for the interaction of peptides with the Kd molecule, and therefore may be acting as an anchor residue. In the present report we show that it is possible to convert a self peptide sequence into a Kd-restricted neo-antigen by a single Tyr substitution at position 2 of the peptide. This supports the idea that Tyr is a critical element in the binding motif of Kd-restricted peptides and is a finding that could also prove useful for vaccine development.
摘要
我们之前发现，一个酪氨酸（Tyr）残基对于肽与Kd分子的相互作用至关重要，因此可能作为一个锚定残基。在本报告中，我们表明通过在肽的第2位进行单个酪氨酸取代，可以将自身肽序列转化为Kd限制的新抗原。这支持了酪氨酸是Kd限制肽结合基序中的关键元素这一观点，并且这一发现也可能对疫苗开发有用。
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