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通过酪氨酸取代将自身肽序列转化为Kd限制的新抗原。

Conversion of a self peptide sequence into a Kd-restricted neo-antigen by a Tyr substitution.

作者信息

Healy F, Drouet C, Romero P, Jaulin C, Maryanski J L

机构信息

Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland.

出版信息

J Exp Med. 1991 Dec 1;174(6):1657-60. doi: 10.1084/jem.174.6.1657.

DOI:10.1084/jem.174.6.1657
PMID:1744590
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2119022/
Abstract

We have previously found that a Tyr residue was critical for the interaction of peptides with the Kd molecule, and therefore may be acting as an anchor residue. In the present report we show that it is possible to convert a self peptide sequence into a Kd-restricted neo-antigen by a single Tyr substitution at position 2 of the peptide. This supports the idea that Tyr is a critical element in the binding motif of Kd-restricted peptides and is a finding that could also prove useful for vaccine development.

摘要

我们之前发现，一个酪氨酸（Tyr）残基对于肽与Kd分子的相互作用至关重要，因此可能作为一个锚定残基。在本报告中，我们表明通过在肽的第2位进行单个酪氨酸取代，可以将自身肽序列转化为Kd限制的新抗原。这支持了酪氨酸是Kd限制肽结合基序中的关键元素这一观点，并且这一发现也可能对疫苗开发有用。

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本文引用的文献

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Immunogenic variants obtained by mutagenesis of mouse mastocytoma P815. III. Clonal analysis of the syngeneic cytolytic T lymphocyte response.通过对小鼠肥大细胞瘤P815进行诱变获得的免疫原性变体。III. 同基因细胞溶解型T淋巴细胞反应的克隆分析。
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Structure of the gene of tum- transplantation antigen P91A: the mutated exon encodes a peptide recognized with Ld by cytolytic T cells.肿瘤移植抗原P91A基因的结构：突变外显子编码一种可被细胞溶解T细胞与Ld识别的肽段。
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Antigen recognition by class I-restricted T lymphocytes.I类限制性T淋巴细胞的抗原识别
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A pentapeptide as minimal antigenic determinant for MHC class I-restricted T lymphocytes.一种作为MHC I类限制性T淋巴细胞最小抗原决定簇的五肽。
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