使用超极化氦-3磁共振标记直接测量肺运动。
Direct measurement of lung motion using hyperpolarized helium-3 MR tagging.
作者信息
Cai Jing, Miller G Wilson, Altes Talissa A, Read Paul W, Benedict Stanley H, de Lange Eduard E, Cates Gordon D, Brookeman James R, Mugler John P, Sheng Ke
机构信息
Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA.
出版信息
Int J Radiat Oncol Biol Phys. 2007 Jul 1;68(3):650-3. doi: 10.1016/j.ijrobp.2007.02.011. Epub 2007 Apr 18.
PURPOSE
To measure lung motion between end-inhalation and end-exhalation using a hyperpolarized helium-3 (HP (3)He) magnetic resonance (MR) tagging technique.
METHODS AND MATERIALS
Three healthy volunteers underwent MR tagging studies after inhalation of 1 L HP (3)He gas diluted with nitrogen. Multiple-slice two-dimensional and volumetric three-dimensional MR tagged images of the lungs were obtained at end-inhalation and end-exhalation, and displacement vector maps were computed.
RESULTS
The grids of tag lines in the HP (3)He MR images were well defined at end-inhalation and remained evident at end-exhalation. Displacement vector maps clearly demonstrated the regional lung motion and deformation that occurred during exhalation. Discontinuity and differences in motion pattern between two adjacent lung lobes were readily resolved.
CONCLUSIONS
Hyperpolarized helium-3 MR tagging technique can be used for direct in vivo measurement of respiratory lung motion on a regional basis. This technique may lend new insights into the regional pulmonary biomechanics and thus provide valuable information for the deformable registration of lung.
目的
使用超极化氦 - 3（HP³He）磁共振（MR）标记技术测量吸气末和呼气末之间的肺运动。
方法和材料
三名健康志愿者吸入用氮气稀释的1L HP³He气体后接受MR标记研究。在吸气末和呼气末获取肺部的多层二维和容积三维MR标记图像，并计算位移矢量图。
结果
HP³He MR图像中的标记线网格在吸气末清晰可见，在呼气末仍然明显。位移矢量图清楚地显示了呼气过程中发生的局部肺运动和变形。两个相邻肺叶之间运动模式的不连续性和差异很容易分辨出来。
结论
超极化氦 - 3 MR标记技术可用于在区域基础上直接在体内测量呼吸时的肺运动。该技术可能为区域肺生物力学提供新的见解，从而为肺的可变形配准提供有价值的信息。
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