用于评估肺局部力学特性的超快磁共振网格标记序列

Ultrafast MR grid-tagging sequence for assessment of local mechanical properties of the lungs.

作者信息

Chen Q, Mai V M, Bankier A A, Napadow V J, Gilbert R J, Edelman R R

机构信息

Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.

出版信息

Magn Reson Med. 2001 Jan;45(1):24-8. doi: 10.1002/1522-2594(200101)45:1<24::aid-mrm1004>3.0.co;2-6.

DOI:10.1002/1522-2594(200101)45:1<24::aid-mrm1004>3.0.co;2-6

PMID:11146481

Abstract

While MR imaging with tagged magnetization has shown great utility in the study of muscle mechanics, the evaluation of pulmonary mechanics has long been hindered by the technical difficulties in MR imaging of lung parenchyma. In this study, a fast MR grid-tagging technique is described for dynamic assessment of regional pulmonary deformation. The method is based on a fast FLASH sequence with short TR and short TE. Tagging was achieved by using double DANTE pulse train or inversion pulses. Our results show that this technique is able to detect changes of the tagging grid caused by physiological deformation of the lung. Quantitative analysis of the data shows that this method is capable of assessing local pulmonary mechanics. The application of this technique could improve our understanding of ventilatory control, and thus provide a unique metric for assessing pulmonary disorders. Magn Reson Med 45:24-28, 2001.

摘要

尽管带有标记磁化的磁共振成像在肌肉力学研究中已显示出巨大的实用性，但肺实质磁共振成像中的技术难题长期以来一直阻碍着肺力学的评估。在本研究中，描述了一种用于动态评估局部肺变形的快速磁共振网格标记技术。该方法基于具有短重复时间（TR）和短回波时间（TE）的快速扰相梯度回波（FLASH）序列。通过使用双绝热快速通过交替激发脉冲序列（DANTE）脉冲串或反转脉冲实现标记。我们的结果表明，该技术能够检测由肺的生理变形引起的标记网格的变化。对数据的定量分析表明，该方法能够评估局部肺力学。该技术的应用可以增进我们对通气控制的理解，从而为评估肺部疾病提供一种独特的指标。《磁共振医学》45:24 - 28, 2001年。