Schier Alexander F
Department of Molecular and Cellular Biology, Harvard Stem Cell Institute, Center for Brain Science, Broad Institute, Harvard University, 16 Divinity Avenue, Room 1027, Cambridge, MA 02138, USA.
Science. 2007 Apr 20;316(5823):406-7. doi: 10.1126/science.1140693.
Maternal gene products drive early development when the newly formed embryo is transcriptionally inactive. During the maternal-zygotic transition, embryonic transcription is initiated and many maternal RNAs are degraded. Multiple mechanisms regulate the birth of zygotic RNAs and the death of maternal RNAs. Genome activation appears to rely in part on the sequestration of transcriptional repressors by the exponentially increasing amount of DNA during cleavage divisions. Maternal RNA degradation is induced by the binding of proteins and microRNAs to the 3' untranslated region of target RNAs.
当新形成的胚胎处于转录不活跃状态时，母源基因产物驱动早期发育。在母源 - 合子过渡期间，胚胎转录开始，许多母源RNA被降解。多种机制调节合子RNA的产生和母源RNA的降解。基因组激活似乎部分依赖于在卵裂过程中随着DNA数量呈指数增加对转录抑制因子的隔离。母源RNA的降解是由蛋白质和微小RNA与靶RNA的3'非翻译区结合所诱导的。
