Tadros Wael, Lipshitz Howard D
Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada.
Development. 2009 Sep;136(18):3033-42. doi: 10.1242/dev.033183.
All animal embryos pass through a stage during which developmental control is handed from maternally provided gene products to those synthesized from the zygotic genome. This maternal-to-zygotic transition (MZT) has been extensively studied in model organisms, including echinoderms, nematodes, insects, fish, amphibians and mammals. In all cases, the MZT can be subdivided into two interrelated processes: first, a subset of maternal mRNAs and proteins is eliminated; second, zygotic transcription is initiated. The timing and scale of these two events differ across species, as do the cellular and morphogenetic processes that sculpt their embryos. In this article, we discuss conserved and distinct features within the two component processes of the MZT.
所有动物胚胎都会经历一个阶段，在此阶段，发育控制从母源提供的基因产物转移到由合子基因组合成的产物上。这种母源向合子的转变（MZT）已在包括棘皮动物、线虫、昆虫、鱼类、两栖动物和哺乳动物在内的模式生物中得到广泛研究。在所有情况下，MZT都可细分为两个相互关联的过程：第一，一部分母源mRNA和蛋白质被清除；第二，合子转录开始。这两个事件的时间和规模在不同物种中有所不同，塑造其胚胎的细胞和形态发生过程也是如此。在本文中，我们讨论了MZT两个组成过程中的保守特征和不同特征。
