Marco Antonio
School of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, CO4 3SQ, UK.
Methods Mol Biol. 2017;1605:1-10. doi: 10.1007/978-1-4939-6988-3_1.
Until the zygotic genome is activated, early development relies on the products deposited by the mother. Once the zygotic genome starts to be transcribed, most maternal products are not needed anymore by the developing embryo. This emancipation from the maternal genome occurs during the Zygotic Genome Activation (ZGA). Although the process by which the maternal content is replaced with zygotic products differs from species to species, there is a common theme to all of them: maternal transcripts are actively degraded. Here, a review of how the degradation of maternal RNAs is regulated during early development and discussions on some computational tools that may be of use in this research area are outlined.
在合子基因组被激活之前，早期发育依赖于母体储存的产物。一旦合子基因组开始转录，发育中的胚胎就不再需要大多数母体产物了。这种从母体基因组的“解放”发生在合子基因组激活（ZGA）期间。尽管母体物质被合子产物取代的过程因物种而异，但它们都有一个共同的主题：母体转录本会被主动降解。在此，概述了早期发育过程中母体RNA降解是如何被调控的，并讨论了一些可能在该研究领域有用的计算工具。
