Chen Jung Yu, Fu Lin Shien, Chu Jao Jia, Chen Hou Chuan, Chi Chin Shiang
Division of Immunology, Rheumatology and Allergy, Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan.
J Microbiol Immunol Infect. 2007 Apr;40(2):168-72.
Atopic diseases are thought to be associated with cytokine-mediated immune dysregulation, for example, a T helper cell type 1/2 (Th1/Th2) imbalance. CD30 is proposed to be one of the surrogate markers for Th2 immunity. In this study, we investigated whether CD30 is a good marker for atopy and Th2 predominance in a pediatric population.
This study included 61 children with atopy and 27 normal controls. The expression of CD30 on the surface of T and B lymphocytes and soluble CD30 (sCD30) in plasma was determined.
There was no difference in the surface expression of CD30 on B or T lymphocytes. Similarly, sCD30 levels in plasma were not different between the 2 groups. Nevertheless, we found a strong negative correlation between sCD30 and age in the control group (r = -0.72, p<0.001; sCD30 = 76.1 - 5.18 x age) as well as in the atopy group (r = -0.45, p<0.01; sCD30 = 61.1 - 3.56 x age).
An inverse relationship was found between age and sCD30 level in children. However, our findings suggest that CD30 is not a good marker for atopic disease and that further studies on sCD30 levels must take age into consideration.
特应性疾病被认为与细胞因子介导的免疫失调有关，例如辅助性T细胞1/2（Th1/Th2）失衡。CD30被认为是Th2免疫的替代标志物之一。在本研究中，我们调查了CD30是否是儿童特应性疾病和Th2优势的良好标志物。
本研究纳入61例特应性疾病患儿和27例正常对照。检测T和B淋巴细胞表面CD30的表达以及血浆中可溶性CD30（sCD30）的水平。
B或T淋巴细胞表面CD30的表达无差异。同样，两组血浆中sCD30水平也无差异。然而，我们发现对照组（r = -0.72，p<0.001；sCD30 = 76.1 - 5.18×年龄）和特应性疾病组（r = -0.45，p<0.01；sCD30 = 61.1 - 3.56×年龄）中sCD30与年龄之间均存在强负相关。
儿童中年龄与sCD30水平呈负相关。然而，我们的研究结果表明CD30不是特应性疾病的良好标志物，并且对sCD30水平的进一步研究必须考虑年龄因素。
