Department of Internal Medicine IV Nephrology and Hypertension, Medical University Innsbruck, Innsbruck, Austria.
Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University Innsbruck, Innsbruck, Austria.
Autoimmun Rev. 2020 Jul;19(7):102570. doi: 10.1016/j.autrev.2020.102570. Epub 2020 May 3.
Now COVID-19 is causing a severe public health emergency and the mortality is rapidly increasing all over the world. In the current pandemic era, although there have been many efforts to diagnose a number of patients with symptoms or close contacts, there is no definite guideline for the initial therapeutic approach for them and therefore, many patients have been dying due to a hyperinflammatory immunological reaction labeled as "cytokine storm". Severe patients are hospitalized and the treatment is done, though they have not been established yet. Currently, however, no treatment is provided for those who are isolated at home or shelter until they get severe symptoms, which will increase the harms to the patients. In this review, we discuss some important points dedicated to the management of patients with COVID-19, which should help reducing morbidity and mortality. In this era, we suggest 7 recommendations to rescue the patients and to reduce the morbidity and mortality due to COVID-19 based on the immunological point of view.
现在，COVID-19 正在引发一场严重的公共卫生紧急事件，全球死亡率正在迅速上升。在当前的大流行时代，尽管已经做出了许多努力来诊断出许多有症状或密切接触的患者，但对于他们的初始治疗方法还没有明确的指南，因此，许多患者因被称为“细胞因子风暴”的过度炎症性免疫反应而死亡。严重的患者住院治疗，但治疗方法尚未确定。然而，目前对于那些在家中或避难所隔离的人，在出现严重症状之前没有提供治疗，这将增加对患者的伤害。在这篇综述中，我们讨论了一些专门针对 COVID-19 患者管理的要点，这将有助于降低发病率和死亡率。在这个时代，我们根据免疫学观点提出了 7 项建议，以拯救患者并降低 COVID-19 的发病率和死亡率。
