Berner Michael M, Kriston Levente, Bentele Michael, Härter Martin
Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Freiburg, Germany.
J Stud Alcohol Drugs. 2007 May;68(3):461-73. doi: 10.15288/jsad.2007.68.461.
The purpose of this study was to perform a systematic review of the diagnostic accuracy of the Alcohol Use Disorders Identification Test (AUDIT) for detecting at-risk drinking.
The MEDLINE, PsycINFO, Science Citation Index Expanded, BIOSIS Previews, Cumulative Index to Nursing and Allied Health Literature (CINAHL), MEDION, and Cochrane Library databases were searched for relevant studies. The criteria for inclusion were a valid reference standard, AUDIT consisting of 10 items, avoiding bias that may result from how the reference standard was obtained, and when and how many participants were tested. Data were extracted independently by two reviewers. Data synthesis was performed by applying direct pooling of proportions and random effects model for likelihood ratios and diagnostic odds ratio.
Twenty-three studies were included in the systematic review, 19 of which were included in the meta-analysis. With a cutoff of 8 points, sensitivity ranged from .31 to .89 and specificity ranged from .83 to .96 across the eight studies conducted in primary care. A single trial in general hospital inpatients found a sensitivity of .93 and a specificity of .94; another trial in emergency-department patients found a sensitivity of .72 and a specificity of .88. A study in university students found a sensitivity of .82 and a specificity of .78. Three studies in elderly patients found sensitivities between .55 and .83 at a pooled specificity of .96. There was large heterogeneity between study results, which could only partly be explained by setting diversity. The analysis of results with population-specific cutoff points led to similar findings.
Findings on the diagnostic performance of the AUDIT proved to be largely heterogeneous. Its use should be restricted to primary care populations, inpatients, and elderly patients.
本研究旨在对酒精使用障碍识别测试(AUDIT)检测危险饮酒的诊断准确性进行系统评价。
检索MEDLINE、PsycINFO、科学引文索引扩展版、生物学文摘数据库、护理学与健康相关文献累积索引(CINAHL)、MEDION和Cochrane图书馆数据库中的相关研究。纳入标准为有效的参考标准、由10个项目组成的AUDIT、避免因参考标准的获取方式以及测试参与者的时间和数量而产生的偏差。由两名审阅者独立提取数据。通过直接合并比例以及对似然比和诊断比值比应用随机效应模型进行数据合成。
23项研究纳入了系统评价,其中19项纳入了荟萃分析。在初级保健中进行的8项研究中,以8分为临界值时,敏感性范围为0.31至0.89,特异性范围为0.83至0.96。一项针对综合医院住院患者的试验发现敏感性为0.93,特异性为0.94;另一项针对急诊科患者的试验发现敏感性为0.72,特异性为0.88。一项针对大学生的研究发现敏感性为0.82,特异性为0.78。三项针对老年患者的研究发现,在合并特异性为0.96时,敏感性在0.55至0.83之间。研究结果之间存在很大异质性,这只能部分归因于研究环境的多样性。使用针对特定人群的临界值进行结果分析得出了类似的结论。
AUDIT诊断性能的研究结果在很大程度上具有异质性。其应用应限于初级保健人群、住院患者和老年患者。