Shiozawa Eisuke, Yamochi-Onizuka Toshiko, Takimoto Masafumi, Ota Hidekazu
Second Department of Pathology, Showa University School of Medicine, 1-5-8 Hatanodai, Tokyo, Japan.
Leuk Res. 2007 Nov;31(11):1579-83. doi: 10.1016/j.leukres.2007.03.017. Epub 2007 Apr 19.
Patients with the germinal center B-cell-like (GCB) subtype of diffuse large B-cell lymphoma (DLBCL) have a significantly better survival rate than those with non-GCB DLBCL. Several studies have examined the proportions of GCB and non-GCB subtypes in large series of DLBCL patients, but it remains unclear if these proportions are the same in different countries. We performed an immunohistochemical analysis of the numbers of GCB and non-GCB subtypes in a large number of patients with DLBCL in Japan and compared the results with literature data for other countries. We found that 71 of 248 patients (29%) had the GCB phenotype and 177 patients (71%) had the non-GCB subtype of DLBCL among our patient population. Assessment of data collected from other studies showed that 31% of DLBCL patients (102/330) have the GCB subtype in Asian countries, but 50% (206/416) express GCB phenotypes in Western countries; based on these data, the occurrence of the GCB subtype of DLBCL was significantly less in Asian countries (p<0.001). Since patients with the GCB phenotype of DLBCL have better survival, future studies of DLBCL should recognize the difference in the proportions of GCB and non-GCB subtypes of DLBCL between Asian and Western populations.
弥漫性大B细胞淋巴瘤（DLBCL）生发中心B细胞样（GCB）亚型的患者生存率明显高于非GCB DLBCL患者。多项研究调查了大量DLBCL患者中GCB和非GCB亚型的比例，但不同国家这些比例是否相同仍不清楚。我们对日本大量DLBCL患者的GCB和非GCB亚型数量进行了免疫组织化学分析，并将结果与其他国家的文献数据进行了比较。我们发现，在我们的患者群体中，248例患者中有71例（29%）具有GCB表型，177例患者（71%）患有DLBCL的非GCB亚型。对其他研究收集的数据评估显示，亚洲国家31%的DLBCL患者（102/330）具有GCB亚型，但西方国家50%（206/416）表现为GCB表型；基于这些数据，DLBCL的GCB亚型在亚洲国家的发生率明显较低（p<0.001）。由于DLBCL的GCB表型患者生存率更高，未来DLBCL的研究应认识到亚洲和西方人群中DLBCL的GCB和非GCB亚型比例的差异。
