Smith Robyn N, Mann Neil J, Braue Anna, Mäkeläinen Henna, Varigos George A
School of Applied Sciences, RMIT University, Melbourne, Victoria, Australia.
J Am Acad Dermatol. 2007 Aug;57(2):247-56. doi: 10.1016/j.jaad.2007.01.046. Epub 2007 Apr 19.
No previous study has sought to examine the influence of dietary composition on acne vulgaris.
We sought to compare the effect of an experimental low glycemic-load diet with a conventional high glycemic-load diet on clinical and endocrine aspects of acne vulgaris.
A total of 43 male patients with acne completed a 12-week, parallel, dietary intervention study with investigator-masked dermatology assessments. Primary outcomes measures were changes in lesion counts, sex hormone binding globulin, free androgen index, insulin-like growth factor-I, and insulin-like growth factor binding proteins.
At 12 weeks, total lesion counts had decreased more in the experimental group (-21.9 [95% confidence interval, -26.8 to -19.0]) compared with the control group (-13.8 [-19.1 to -8.5], P = .01). The experimental diet also reduced weight (P = .001), reduced the free androgen index (P = .04), and increased insulin-like growth factor binding protein-1 (P = .001) when compared with a high glycemic-load diet.
We could not preclude the role of weight loss in the overall treatment effect.
This suggests nutrition-related lifestyle factors play a role in acne pathogenesis. However, these preliminary findings should be confirmed by similar studies.
此前尚无研究试图探讨饮食构成对寻常痤疮的影响。
我们旨在比较实验性低血糖负荷饮食与传统高血糖负荷饮食对寻常痤疮临床及内分泌方面的影响。
共有43名患痤疮的男性患者完成了一项为期12周的平行饮食干预研究，由对研究者设盲的皮肤科医生进行评估。主要结局指标为皮损计数、性激素结合球蛋白、游离雄激素指数、胰岛素样生长因子-I及胰岛素样生长因子结合蛋白的变化。
12周时，与对照组（-13.8 [-19.1至-8.5]，P = 0.01）相比，实验组的总皮损计数下降得更多（-21.9 [95%置信区间，-26.8至-19.0]）。与高血糖负荷饮食相比，实验性饮食还能减轻体重（P = 0.001）、降低游离雄激素指数（P = 0.04）并增加胰岛素样生长因子结合蛋白-1（P = 0.001）。
我们无法排除体重减轻在整体治疗效果中的作用。
这表明与营养相关的生活方式因素在痤疮发病机制中起作用。然而，这些初步发现应由类似研究加以证实。
