Department of Dermatology, International St. Mary's Hospital, College of Medicine, Catholic Kwandong University, Incheon 22711, Republic of Korea.
Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Int J Mol Sci. 2024 May 13;25(10):5302. doi: 10.3390/ijms25105302.
Acne vulgaris is a common dermatological condition that can present across different ages but predominantly affects adolescents and young adults. Characterized by various lesion types, the pathogenesis of acne is complex, involving genetic, hormonal, microbial, and inflammatory factors. This review comprehensively addresses current and emerging acne management strategies, emphasizing both topical and systemic treatments, procedural therapies, and dietary modifications. Key topical agents include retinoids, benzoyl peroxide, antibiotics, and other specialized compounds. Systemic options like antibiotics, hormonal therapies, and retinoids offer significant therapeutic benefits, particularly for moderate to severe cases. Procedural treatments such as laser devices, photodynamic therapy, chemical peels, and intralesional injections present viable alternatives for reducing acne symptoms and scarring. Emerging therapies focus on novel biologics, bacteriophages, probiotics, and peptides, providing promising future options. This review underscores the importance of personalized approaches to treatment due to the multifaceted nature of acne, highlighting the potential of innovative therapies for improving patient outcomes.
寻常痤疮是一种常见的皮肤科疾病，可发生于不同年龄段，但主要影响青少年和年轻人。其特征为各种皮损类型，痤疮的发病机制复杂，涉及遗传、激素、微生物和炎症因素。本综述全面介绍了当前和新兴的痤疮管理策略，强调了局部和全身治疗、程序治疗和饮食调整。关键的局部治疗药物包括维 A 酸类、过氧化苯甲酰、抗生素和其他特殊化合物。抗生素、激素疗法和维 A 酸类等全身性药物治疗对中重度痤疮具有显著的治疗益处。激光设备、光动力疗法、化学换肤和皮损内注射等程序治疗为减轻痤疮症状和瘢痕提供了可行的替代方法。新兴的治疗方法侧重于新型生物制剂、噬菌体、益生菌和肽，为改善患者预后提供了有前途的未来选择。由于痤疮的多因素性质，本综述强调了针对治疗方法的个体化方法的重要性，突出了创新疗法改善患者结局的潜力。
