Hamed Sherifa A, Hamed Enas A, Hamdy Ragaa, Nabeshima Toshitaka
Department of Neurology, Assiut University Hospital, Assiut, Egypt.
Epilepsy Res. 2007 May;74(2-3):183-92. doi: 10.1016/j.eplepsyres.2007.03.010. Epub 2007 Apr 19.
This study aimed to evaluate the carotid artery intima-media thickness (CA-IMT) in adult patients with epilepsy and its contribution to oxidative stress and vascular risk biomarkers.
This study included 225 adult epileptic and 60 control subjects. For all, CA-IMT, fasting lipid profile (TC, TG, HDL-c and LDL-c), total homocysteine (tHcy), von Willbrand factor (vWF), fibrinogen, oxidized LDL (Ox-LDL), malondialdehyde (MDA), thiobarbituric acid reactive substances (TBARs), uric acid, total antioxidant capacity (TAC) and glutathione peroxidase (GSH.Px), were assessed.
Compared to control group, the IMT of patients' common carotid artery, bifurcation area and internal carotid arteries was significantly thickened in 51.1%, 73.3% and 43.6% in various groups of patients (treated and untreated). In the studied patients, the levels of tHcy, vWF, fibrinogen, MDA, TBARs, Ox-LDL levels were increased while HDL-c and TAC were decreased. Patients on CBZ showed the most significant changes in the levels of tHcy, vWF and HDL-c while patients on VPA showed significant alteration in uric acid, TBARs and GSH.Px.
This study supports that in patients with epilepsy, various vascular risk factors and CA-IMT, get worse which could be attributed to epilepsy itself and/or its antiepileptic medications.
本研究旨在评估成年癫痫患者的颈动脉内膜中层厚度（CA-IMT）及其对氧化应激和血管风险生物标志物的影响。
本研究纳入了225名成年癫痫患者和60名对照受试者。对所有人评估了CA-IMT、空腹血脂谱（总胆固醇、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇）、总同型半胱氨酸（tHcy）、血管性血友病因子（vWF）、纤维蛋白原、氧化型低密度脂蛋白（Ox-LDL）、丙二醛（MDA）、硫代巴比妥酸反应性物质（TBARs）、尿酸、总抗氧化能力（TAC）和谷胱甘肽过氧化物酶（GSH.Px）。
与对照组相比，在各患者组（治疗组和未治疗组）中，患者颈总动脉、分叉处和颈内动脉的内膜中层厚度在51.1%、73.3%和43.6%的患者中显著增厚。在研究的患者中，tHcy、vWF、纤维蛋白原、MDA、TBARs、Ox-LDL水平升高，而高密度脂蛋白胆固醇和总抗氧化能力降低。服用卡马西平（CBZ）的患者tHcy、vWF和高密度脂蛋白胆固醇水平变化最为显著，而服用丙戊酸（VPA）的患者尿酸、TBARs和谷胱甘肽过氧化物酶有显著改变。
本研究支持癫痫患者中各种血管危险因素和CA-IMT会恶化，这可能归因于癫痫本身和/或其抗癫痫药物。
