Palencia Guadalupe, Calderon Alejandra, Sotelo Julio
Neuroimmunology Unit, National Institute of Neurology and Neurosurgery, Insurgentes Sur 3877, 14269 Mexico City, Mexico.
J Neurol Sci. 2007 Jul 15;258(1-2):128-31. doi: 10.1016/j.jns.2007.03.010. Epub 2007 Apr 23.
Thalidomide was originally synthesized and tested as a sedative, hypnotic and antiemetic; however, after its teratogenicity was noted its use for treatment of neurological and psychiatric disorders was abandoned. We studied the potential anticonvulsant effect of thalidomide: Different doses of thalidomide were tested against seizures induced by 50 mg/kg or 70 mg/kg of pentylenetetrazole (PTZ); the anticonvulsant effect of thalidomide was also compared with that of valproic acid. Seizures and latency time were individually recorded. Thalidomide in low doses (5-10 mg/kg) prevented seizures in all animals treated with 50 mg/kg PTZ; also, in a dose-dependent manner thalidomide inhibited seizures in rats exposed to a high dose of PTZ (70 mg/kg); thalidomide exhibited an anticonvulsant activity similar to that of valproic acid. Thalidomide is an effective anticonvulsant, and further studies on this potential antiepileptic substance seem warranted.
沙利度胺最初是作为镇静剂、催眠剂和止吐剂合成并进行测试的；然而，在其致畸性被发现后，其用于治疗神经和精神疾病的用途被放弃。我们研究了沙利度胺的潜在抗惊厥作用：测试了不同剂量的沙利度胺对50毫克/千克或70毫克/千克戊四氮（PTZ）诱导的癫痫发作的影响；还将沙利度胺的抗惊厥作用与丙戊酸的抗惊厥作用进行了比较。分别记录癫痫发作和潜伏期。低剂量（5 - 10毫克/千克）的沙利度胺可预防所有接受50毫克/千克PTZ治疗的动物发生癫痫发作；此外，沙利度胺以剂量依赖的方式抑制暴露于高剂量PTZ（70毫克/千克）的大鼠的癫痫发作；沙利度胺表现出与丙戊酸相似的抗惊厥活性。沙利度胺是一种有效的抗惊厥剂，对这种潜在的抗癫痫物质进行进一步研究似乎是有必要的。
